The Clinical Sduty Of CIK Cells Are Intrapleural Infused,Combined With Warming The Lung To Reduce Watery Phlegm For The MPE Treatment

Objecti vesChoosing the best option and rational use of combination therapy to improve survival of MPE (malignant pleural effusion) patients and quality of life is very necessary and with important clinical significance.In this study, the changes in MPE, T-Cell Subsets and NK cell before and after treatment, symptom scores, and KPS score changes would be observed. The safety and efficacy of CIK cells combined with warming the lung to reduce watery phlegm would be evaluated by statistical analysis in order to explore the better treatment of MPE.MethodsThe cases of MPE patients diagnosed in line with the standards were chosen for the research. Then the patients were randomly divided into two groups,25cases of the experimental group, and21cases of the control group.Before the treatment starts, each patient would be evaluated including their symptoms, KPS score, and check the relevant indicators.The treatment of control group:Lentinan and Cisplatin are intrapleural infused, combined with taking the Chinese medicine of warming the lung to reduce watery phlegm.The treatment of experimental group:Compared with control group, there are CIK cells more for intrapleural infusion.4weeks and8weeks after the treatment, MPE changes would be reviewed, each patient would be evaluated including their symptoms scores and KPS score, and check the relevant indicators again.Then take a statistical analysis for the variables above-mentioned, to evaluate the safety and efficacy of the two methods.Result1. Compared with the control group, no matter4weeks or8weeks after the treatment, the ORR and DCR of the experimental group are in the ascendant.2.4weeks after the treatment, the comparisons of CD3+cells, CD8+cells, and CD4+/CD8+between2groups were statistically significant differences (P<0.05). Compared with that before the treatment, the CD8+cells of8weeks after the treatment was statistically significant differences (P <0.05).3.4weeks after the treatment, the ORR of KPS score was60.0%in the experimental group while the control group were47.6%.8weeks after the treatment, the ORR of KPS score was44.0%in experimental group while control group were38.1%.In the Box and whisker, Compared with4weeks, the KPS score of8weeks in the experimental group held the line, while the control group reduced.4.4weeks after the treatment, choking sensation in chest, dyspnea and the total score of symptoms of2groups were statistically significant differences (P<0.05).8weeks after the treatment, dyspnea and the total score of symptoms of2groups were statistically significant differences (P<0.05).In the Box and whisker, Compared with the4weeks, choking sensation in chest, dyspnea and the total score of symptoms of8weeks in the experimental group held the line, while the control group rose again.5. Adverse response in both groups was less and no significant difference between the side effects of2groups.Conelusion1. Compared with the control group, the experimental group can be more effective in control of the MPE.2. CD3+cells and CD8+cells of T-Cell Subsets of the experimental group were improved significantly in4weeks, while CD8+cells were improved significantly in8weeks.3. Compared with the control group, the improvement of KPS score and the symptoms of the experimental group were more significant. And the treatment of the experimental group was more stable.4. Adverse response in both groups is less. And both groups possess the merits of good security.5. The therapy of CIK cells combined with warming the lung to reduce watery phlegm for the MPE would be applied in the conditional clinical units.