The Research On Preparation And Quality Control For Xiancidan

Compound Xiancidan Anti-cancer pill derived from a hospital of Guangdong, which consists of11herbs such as herba Scutellaria barbata, herba Pleione bulbocodioides, herba Caesalpinia sappan, herba Bupleurum scorzonerifolium, ect. Therefore it can be chiefly used to treat malignant tumors. In this study, the praeparatum is developed to maintain the effectiveness and characteristics of the original decoction, so as to reduce toxicityAnd facilitate the patients. With the guidance of the theories of Traditional Chinese Medicine Xiancidan Anti-cancer pill was studied with modern pharmaceutical technology. On the basis of research on Preparation and Quality Control. The method and results as follows:1Preparation technologyTo maintain the effectiveness and characteristics of the original decoction. Regarding the total solid rate and the extraction rate of scutell-arin as indexes, the optimum technical parameters of the water extracting technology were as follows:adding12times water to the original crude materials, being fried and boiled three times and for0.5h each time.The influence of concentration on the retention rates of scutellarin. The optimum conditions for concentration were as follows:film vacuum evaporation was used for concentration of water extraction, the vacuum was controlled in-0.07～-0.08Mpa, and the relative density of concentrate was about1.12.The metastasis rates of scutellarin and baicalin were more than90%in this process.When it comes to molding process, the final thick paste and herba powder mixed, build models per1000g herba powder with41～43g powder,with2types filter the pills. drying after spraying under the bottom of the pot.2. Quality controlThe methods of TLC identification for Scutellaria barbata, Caesalpinia sappan, Curcuma longa, Panax notoginseng (Burk.)F. H. Chen, Herb of Spreading Hedyotis in the preparation were established.The methodology of HPLC determining scutellarin and Ginsenoside Rbl content of the preparation was investigated systematically.These methods were easily oprated, and were good at specificity and repeatability. The qualities for Xiancidan were conformed as follow:the scutellarin content per gram should be more than0.5mg.