A Study Of Metabolic Disturbances Of Vitamin D And Parathormone In Non-cholestatic Chronic Liver Disease

Objective:To investigate the prevalence and type of vitamin D and parathyroid hormone(PTH) disturbance in patients with noncholestatic chronic liver disease(CLD). Methods:we studied26health and62cases of noncholestatic CLD(involve cirrhosis),The severity of cirrhosis was graded using the Child-Pugh score, serum concentrations of25-hydroxy vitamin D3and PTH were measured with enzyme linked immunosorbent assay and chemiluminescence,then compared and analysised。Pearson correlation coefficien were calculated between25-OH-VitD3and other variables.Results The25-OH-VitD3level in experience group was22.20±17.64ng/ml,the control group was30.71±7.35ng/ml,there has statistical significance.Secondary hyperparathyroidism was present in8patients(12.9%). The prevalence of VitaminD3deficiency was significantly higher in cirrhosic vs noncirrhosic(18.09vs24.85ng/ml).In Child-pugh class C patients25-OH-VitD3level was sinigificantly lower than in class A patients (23.01±7.74vs12.76±8.07,p=0.02). serum25-OH-VitD3independently correlated with total bilirubin、INR、PT (negatively); serum albumin、CHE、PLT (positively). No significant correlation was seen in vitaminD and PTH, calcium and phosphate levels.Conclusions:Vtamin D inadequacy and the severity of liver dysfunction move in parallel in patients with noncholestatic chronic liver disease,secondary hyperparathyroidism is relatively infrequent. Serum PTH concentration showed no significant correlation with the the severity of liver disease and serum vitamin D concentrations.