| Objective To evaluate the expression of Tim-3and its clinical significance in the gastric cancer tissues.Methods52gastric cancer specimens were detected for Tim-3by flow cytometry, and15specimens of gastritis tissues served as the control. For all statistical analyses, SPSS13.0computer software was used.Results Tim-3expressed both in gastric cancer and gastritis tissues. In CD4+T cells, The expression level of Tim-3in gastric cancer tissues (12.4±8.41)%was significantly higher than gastritis tissues(6.01±1.95)%; In CD8+T cells, The expression level of Tim-3in gastric cancer tissues (9.56±7.48)%was significantly higher than gastritis tissues(5.39±2.98)%(P<0.005). Tim-3expression in CD4+T cells was significantly associated with clinicopathological features such as invasion depth, lymph node metastasis and TNM stage (P<0.05). No correlation was found between Tim-3and gender, age, tumor size and histological type (P>0.05). In CD8+T cells, Tim-3expression correlated with TNM stage rather than other clinicopathological features.Conclusion Tim-3played an important role in the invasion and metastasis of gastric cancer, and was a prognostic factor for poor outcome. |
