The Clinical Study On CRRT In SIRS With Capillary Leak Syndrome

objection:Observed the therapeutic effect for Continuous renal replacement therapy (CRRT) for systemic inflammatory response syndrome (SIRS) with capillary leak syndrome(CLS).Method:A prospective, interventional study was conducted in the intensive care department of SIR Run Run Shaw hospital of Zhejiang University from, According to systemic inflammatory response syndrome(SIRS) and capillary leak syndrome(CLS) diagnostic criteria,38patients were enrolled from January1,2011to January1,2012.The patients were divided into two groups:study group (n=18) accept CRRT therapy, and the control group (n=20) do not accept CRRT therapy.and the both group accept comprehensive therapy In the24hours after the CLS appeared. before treatment and24h,48h and72h after,The date were recorded about the vital sign, related biochemical parameters, extravascular lung water (EVWL), pulmonary vascular permeability index (PVPI), APACHE II, The hospital day in ICU, the mortality. The analysis was performed using the SPSS13.0statistical software package, A p value <0.05was considered statistically significantResult:compared with the time points of Oh before treatment and24h,48h,72h after treatment, the hemodynamics parameters, oxygenation index and breathing, extravascular lung water, pulmonary vascular permeability index of two groups were obviously improved(Compared with before treatment P<0.05). The change of the study group(CRRT group) were more significant (compared with control group P<0.05); After treatment, the APACHE Ⅱ levels of two groups were significantly reduced (compared with the levels before treatment, P<0.05), and the change of patient’s level of the study group(CRRT group) were more significant (compared with the control group, P<0.05). The hospital day in ICU of patients were obviously shorter, and the mortality was lower in the CRRT group than those in the control group.Conclusion:the patients accepted CRRT treatment can effectively improve inflammation, improve the vascular permeability and consequently improve disease.