Expression Of NNMT And Its Relationship With Dinicopathologic Features In Breast Cancer

ObjectiveTo study the expression of NNMT and its relationship with clinicopathologic features in breast cancer.MethodsWe studied42patients with breast cancer and collected their clinical data including: age, tumor size, histology, edmondson grade, lymph node metastases, expression of ER, PR, CerbB-2, P53and serum levels of CEA and CA153.The42patients’ postoperative pathologic wax blocks were selected as study group and20cancer side tissues from the42patients were selected as control group. The expression levels of NNMT in both groups were detected by immunohistochemistry. The relationship between the expression of NNMT and the clinicopathologic features of breast cancer was analyzed to investigate the possible role on NNMT in patients with breast cancer Results1. The expression of NNMT protein in breast cancer tissues (73.8%) was significantly higher than that in the cancer side tissues.2. NNMT protein was found to be diffusely expressed both in cytoplasm and nucleus of breast cancer tissues, but mainly in the former.3. No significant association were found between NNMT expression and age, size of tumor, histology, edmondson grade, lymph node metastases, levels of ER, CerbB-2of breast cancer patients(P>0.05). Interestingly, we observed that NNMT expression was positively correlated with PR and P53status.ConclusionsNNMT is over-expressed and associated with PR and P53status in breast cancer, which may become as a possible tumor marker indicating diagnosis and treatment of breast cancer.