The Clinical And Pathological Features Of The GI Tract Neuroendocrine Neoplasms

BackgroundNeuroendocrine neoplasm (NEN) was thought to be a rare tumor, but recent research has proved that the incidence of NEN has increased by500%, until now, it has become the second most common tumor in the gastrointestinal tract. So it is important for the clinicians to know the basic characteristics of NEN.Materials and MethodsAll cases involving are patients received operation and diagnosed as NEN by pathology between March2000and March2011in the second affiliated hospital of Zhejiang university college of medicine.ResultsThere are125cases,84males and41females, among them, esophagus23, stomach and duodenum73, jejunoileum8, colorectum21. The distribution of NEN are associated with age, sex、primary location. When diagnosed,85.6%of the complain is related to direct growth of the primary mass,8%are the metastatic synptoms. About70.8%of the patients with NEN are in regional or further metastasis. The average diagnostic time is7.41±1.828months. According to the correlation study, we know that age of onset is related to sex, primary complaint is related to the site of the tumor(P<0.01), tumor size and primary site of tumors are related to tumor staging(P<0.05).ConclusionMan has a higher risk of GI tract neuroendocrine neoplasms than women, especially for man at the average age of70years. Most of the tumor located in the upper GI tract, colon and rectum. During the first diagnosis, the average size of the tumor is5.35±3.11cm, and about70%of them have regional or far-away metastasis. The bigger the tumor size and the lower GI tract the tumor locate, the later the tumor clinical and pathological staging will be, while age, sex, diagnostic time, diagnostic syndrome is not influenced.