Influence Of Passive Smoking On Mesh In Female Rats Of Birth Trauma

Objective：The aim of this study was to observe the relationship between passivesmoking and the vaginal mesh erosion rate in female rats of Birth Trauma,discuss its possible mechanism and providing further theoretical andexperimental evidence for clinical treatment.Methods：60female Wistar rats were established a model of female Birth Traumaand implanted polypropylene mesh into posterior vaginal wall and thenrandomly divided into4groups:（1）normal control group—no smoking group,（2）smoking group（M）,（3）castration group （OVX）,（4）castration plussmoking group（M+OVX）,15in each group. The control and castration groupsfed normally while the smoking and castration plus smoking groups smoked for3months. Observing the situation of vaginal mesh erosion, all rats were killedat3months after getting blood. The serum E₂and FSH levels were measured byenzyme linked immunosorbent assay（ELISA）. The data were analyzed withSPSS11.5for Windows.Results:①The ELISA showed that the serum levels of estrogen were significantlylower both in the smoking group and castration group than those in normalcontrol group （both P <0.01），as so as castration plus smoking group thancastration group （P<0.05）. The serum levels of follicle-stimulating hormonewere significantly higher in the smoking group and castration group than thosein normal control group （both P <0.01），as so as castration plus smoking group than castration group （P<0.01）.②The result of the vaginal mesh erosion rate showed that rate of normalcontrol group was26.67%, smoking group was46.67%,castration group was66.67%and castration plus smoking group was80.00%Conclusion:①Passive smoking can make ovarian function injured in non-castration rats and cause reproductive endocrine disorders—higher FSH leveland lower E₂level.②Passive smoking may be a kind of risk factor on mesh erosion.③The higher mesh erosion rate may be concerned with lower E₂level.