The Clinical Research Of The Related Factors Of Epilepsy Secondary To Viral Encephalitis

Epilepsy is a chronic disease of the nervous system which is caused byabnormal synchronized discharge of neurons. Encephalitis is a significant causeof secondary epilepsy. Most epilepsy that secondary to encephalitis arerefractory epilepsy. The effect of antiepileptic drug therapy is notsatisfactory. Sometimes requires use combined medication. It takes seriouseconomic burden to patients and society. At present epilepsy secondary toencephalitis have attracted the attention of the majority of scholars. This articleintend to further explore the characteristics of seizure type, EEG and MRI, aswell as drug treatment,and in the epilepsy secondary to encephalitis.Case information came from the first hospital of Jilin University.wecollected of139cases of hospitalized inpatients,men83cases,female56cases,which is diagnosed as epilepsy secondary to encephalitis from February2006to June2011,and all their Information integrity. The diagnose standardsaccording to the classification standards made by International Union ofantiepileptic in1981.We analysised the general data, clinical characteristics,EEG and imaging findings, and treatment. Results found that epilepsysecondary to encephalitis patients with slightly more men than women.Average age is36.12years. The age between20to4o years (contains40years)takes the most percentage,43.17%;The age that greater than60years only takes7.91%.In the seizure type, partial seizures is the most common,63.31%(88/139);and the generalized seizure secondary to partial seizures is more common in thepartial seizures,69.32%(61/88). Record the patients’ seizures number,thenumber only seizures once during the course is30cases(21.58%), theeffective of treatment is100%;2～6times54cases(38.85%), the effective of treatment is98.15%;more than7times(contain7times)55cases (39.57%). theeffective of treatment is80%.The typical change of EEG examination isthat the sharp wave,spike wave,and sharp-slow-wave which representativeepilepsy present on the basis of slow-wave,such as θ wave,δ wave.The cases alldid the EEG check,114cases did the EEG,10cases did AEEG,15cases didVEEG.Only7cases perform normal,others all have different levelabnormal.There were6cases perform Severe abnormal,and2of them died.VEEG detection rate of clinical onset is(60%), much better than the AEEGand EEG.132cases do the MRI examination,70cases have abnormal signal, thepositive rate is53.03%. The abnormal of MRI findings for temporal lobes,Hippocampus and insular, frontal lobe abnormal signals;gray matter and whitematter all maybe suffered, but dominated by gray matter, T1WI low signal,T2WI high signals, DWI is a high signal. Lesions can be involved on one side,or bilateral involvement. And the insular cortex, Hippocampus and temporallobe area involved is the most common.There are4cases that the first MRIwithout visible abnormaly,but the second MRI after half a month showeabnormal signal.72cases only use diazepam, Phenobarbital sodium and so onwhen epileptic seizures,don’t use AEDs.67cases give AEDs at the sametime.44cases give single drug,19cases give two kinds of drugs,4cases givecombined of three kinds of antiepileptic drugs.As a result,127cases patient’symptom are better than admitted to hospital,4cases’treatment has no effect,2cases dead, go to other hospital or waiver6cases.The total treatment effectiverate is92.8%.Therefore, encephalitis is the main cause of secondary epilepsy in youngpeople. Partial seizures is the most common attack type, Particular thegeneralized seizure secondary to partial seizures. EEG is an important assistantexamination, VEEG detection rate of clinical onset is much better than theAEEG and EEG. EEG may reflect the severity and changes.In the beginning of inflammation,MRI may be normal, if necessary,we can do it again after a time.We should give the patients whose epilepsy secondary to encephalitis activeanti-virus treatment in the early stage. Antiepileptic treatment whennecessary,Antiepileptic treatment is still dominated by drug treatment. Whensingle-drug treatment can’t be satisfactory, considering the combination.