Comparison Of The Effect On P Wave Dispersion Between-receptor Blockers And Antithyroid Drugs In Short-term Treatment Of Patients With Hyperthyroidism

Objective:To determine the changes of P wave dispersion (PWD) in patients with hyperthyroidism, and to compare the short-term effect of propranolol and propylthiouracil in treatment of PWD.Methods:Thirty patients with initial hyperthyroidism were randomly divided into a propylthiouracil group and a propranolol group, and were given propylthiouracil tablets100mg,3times/d, oral and propranolol tablets10mg,3times/d, oral for three weeks, respectively. The12-lead electrocardiography was applied to record the P wave values before and after treatment. The PWD were obtained by calculating the differences of the maximum and minimum of the P wave values (Pmax and Pmin).Results:(1) The PWD of the hyperthyroidism patients who were treated with propylthiouracil and propranolol for a short term were improved significantly.(2) The decrease of PWD in the propranolol group was more significant than that in the propylthiouracil group.Conclusion:(1) The short-term therapy of propranolol can significantly improve the PWD of hyperthyroidism patients.(2) The PWD improvement of the hyperthyroidism patients by propranolol is more significant than that by propylthiouracil in short-term treatment.(3) The improvement of PWD by propranolol may be through the reduction of triiodothyronine (T3) level to suppress sympathetic nerve activity, while the improvement of PWD by propylthiouracil may be through the reduction of thyroxine level.