Correlation Study On Serum Monocyte Chemoattractant Protein-1Level And Coronary Heart Disease

Objective:To observe the expression of monocyte chemoattractant protein-1in normal control groupand coronary heart disease group, which include stable angina pectoris group, unstable anginapectoris group and acute myocardial infarction group. We analyzed the relationship amongmonocyte chemoattractant protein-1and acute coronary syndrome, the coronary collateralcirculation formation, highly sensitive C-reactive protein, coronary lesions degree,left ventricularfunction, and we explore the possible mechanism.Methods:153inpatients with coronary angiography were enrolled and their data were analyzed. Theirblood samples should be taken before coronary angiography. Patients were divided into coronaryheart disease group (n=123) and normal control group; coronary heart disease group was dividedinto acute coronary syndrome group (n=93, include unstable angina pectoris51cases, and acutemyocardial infarction42cases) and stable angina pectoris group. Acute coronary syndromegroup is divided into coronary collateral circulation group and control group according toRentrop’s collateral classification. The serum concentration of MCP-1was determined by ELISA.We judged coronary collateral circulation degree with Rentrop，s rating criteria, we evaluated thecoronary lesions serious degree with Gensini scoring methods, and we used the ultrasoniccardiogram to evaluate left ventricular ejection fraction.Results:1.The serum levels of MCP-1of control group, the stable angina pectoris group group, theunstable angina pectoris group, and acute myocardial infarction group were52.36±3.48pg/ml,53.73±2.49pg/ml,113.32±22.75pg/ml,114.07±21.29g/ml respectively. There was statisticalsignificance in ACS group and SAP group (P <0.01); there was statistical significance in ACSgroup and control group (P <0.01);2. In CHD group, it is no correlated between serum MCP-1levels and Gensini score. r=0.151,(P=0.095),3.In CHD group,it is positively correlated between serum MCP-1levels and highly sensitiveC-reactive protein, r=0.511,(P <0.001).4. In CHD group, it is negatively correlated between serum MCP-1levels and LVEF, r=-0.597,(P <0.001). 5. In ACS group, serum MCP-1levels of the patient with Rentrop0level was74.88±4.67pg/ml, Rentrop1level was108.04±2.85pg/ml, Rentrop2level was124.31±3.51pg/ml,Rentrop3was136.04±2.04pg/ml. It is positive related between the serum levels of mcp-1andRentrop’s grade, r=0.591,(P <0.01).Conclusions:MCP-1levels is higher in ACS group, MCP-1can be used to predict the occurrence of acutecoronary syndromes, MCP-1levels is positively correlated with highly sensitive C-reactiveprotein,MCP-1levels is no correlated with Gensini score and It is related to instability ofcoronary plaque.MCP-1levels is negatively correlated with Left ventricular ejection fraction andit can be used for the evaluation of left ventricular function.MCP-1levels is positively correlatedwith Rentrop’s grade and it may promote the formation of coronary collateral circulation.