Influence Of Palliative Radiotherapy On Prognosis And Quality Of Life For Patients WithⅣStage Non-small Cell Lung Cancer

Objective：The purpose of this study was to investigate the impact of palliative radiotherapy onⅣnon-small cell lung cancer prognosis and survival quality and findⅣof non-small cell lungcancer radiation therapy and long-term survival of an independent prognostic factor for thefuture to more accurately determine the prognosis ofⅣNSCLC, choose the best treatmentprograms provide a reference.Methods：Collected from January 2000 to December 2009 can not continue to toleratechemotherapy or other reasons not accepted palliative radiotherapyⅣstage non-small cell lungcancer, 318 cases of patients with clinical data line systemic chemotherapy. K-M method, thecalculation of survival rate, the log-rank univariate analysis, Cox regression line multi-factoranalysis. The study of prognostic factors include: age, treatment KPS score, gender, pathologicaltype, whether the brain metastasis, brain metastases of whether bone metastases, bone metastasesof transfer of organs the number of the primary tumor radiation dose.Results: Until the last follow-up in April 2011, 43 cases of survival, 228 cases of death, lost to16 cases in one year, two years lost to the 30 cases, 47 cases of cut-off lost to follow-up JCP.Patient follow-up period of 2 to 42 months median follow-up time was 22 months. Deaths in 197cases died of tumor-related diseases. The median survival time of seven months, and 2-yearsurvival rates were 25.2%, 7.4%. 1, 2-year survival of 318 patients, median survival time was25.2%, 7.4%, 7. Symptoms response rate after radiotherapy: cough 72.4%, chest pain 80.6%,hemoptysis 88.1%, dyspnea 60.8%, hoarseness (19.2%), bone metastasis pain and symptoms ofbrain metastases and signs of varying degrees of ease or even disappear: bone metastases of76.8%, brain transfer of 75.7%. Univariate analysis showed that: KPS score, pathological typesof brain metastases, multi-organ metastasis, primary tumor radiation dose was associated withprognosis, multivariate analysis showed: KPS score, multiple organ metastasis is an independentprognostic factor for patient survival.Conclusion: Palliative radiation therapy to relieve symptoms and improve quality of life andprolong the survival of the role of playⅣNSCLC treatment. KPS score, multiple organmetastasis is an independent prognostic factors.