The Preliminary Research Of Gemstone Spectral CT Imaging For Lung Cancer Biological Therapy Observed Value

Objective By measurement and analysis the lung cancer patients different single-energthe tumor CT value and the tumor iodine content changes,to explore the value of CT spectralimaging for biological therapy of lung cancer.Methods 40 cases biological therapy of lung cancer patients（20 cases were central lungcancer , 20 cases were peripheral lung cancer）were underwent spectral CT normal andenhancement scan. In gemstone spectral imaging viewer (GSI viewer) software, lung cancerpatients were measured the different single-energ(40keV-140keV) the tumor CT value and thetumor iodine content on the iodine-based image of before and after the biological therapy ,analysed the datas and paired t-test.Results40 cases patients with lung cancer in diferent single energy 50keV、70keV、90keV、110keV、130keV, its CT values of tumor before and after the biological therapy were:133.38±17.26 and 99.01±18.42（HU）、75.92±14.10 and 53.62±13.81（HU）、49.47±13.39 and28.83±7.50（HU）、43.53±12.25 and 22.97±7.31（HU）、37.37±12.13 and 17.01±4.50（HU）.Iodine content of the tumor region of interest (ROI) in biological pre-therapy was 2.65±0.35（g/L），and biological post-therapy was 1.56±0.38（g/L）.By paired t-test, differentsingle-energy CT value and iodine content in post-therapy were lower than that in pre-therapydifferent between pre-therapy and post-therapy . The difference between the two groups wasstatistically significant (P <0.05).Conclusions1. Gemstone CT spectral imaging was a noninvasive and rapid screening method , andcould provide more valuable qualitative and quantitative information through the single-energyand iodine-based analysis of lung cancer.2. By spectral imaging and material separation technology , gemstone spectral CT could geta more detailed assessmeny of the effects after the biological therapy of lung cancer .