The Study On Camellia Chrysantha Reduces Risk Of Atherosclerosis

Objective:Discussion on the role of Camellia chrysantha prevent atherosclerosis in the aging body. Methods:40male SD rats, weight180-220g, randomly divided into4groups, each group of10, normal control group (N), respectively, aging group (A), high concentrations of Camellia chrysantha group(HC) and low concentrations of Camellia chrysantha group(LC). Group of drugs used in model groups and2group d-Galactose successive intraperitoneal injection of200mg/(kg·d) preparation of animal model of acute senile,1/d, a total of40days. A group modeled after the success of the model is no longer doing anything. Tea set of rat model of drug use after the success of Camellia chrysantha one set every day intragastric infusion with2g/kg boiled water, the other one group4g/kg intragastric infusion with water every day,1/d, a total of40days. Intragastric infusion with N group rats every day the same dose of normal saline, groups of rats with medication. Tail vein in rats after intragastric infusion with last access contents of blood testing TC, TG, HDL-C, LDL-C, and broken neck executed preparation of liver tissue of rats measured MDA, SOD, TC, TG content and expression of bax, bcl-2mRNA levels.Results:(1)The A group liver MDA levels significantly elevated compared with N group (P<0.05) and SOD contents significantly lower than N group(P<0.05); HC and LC group significantly reduced liver MDA levels than the A group(P<0.05) and SOD contents significantly higher than N group(P<0.05); Comparison between HC and LC group, the indicators there are statistically significant differences (P<0.05).(2) the A group serum HDL-C levels significantly lower than N groups (P<0.05) and serum TC and TG, LDL-C content significantly higher than N group(P<0.05);HC and LC group HDL-C content model for A group significantly increased (P<0.05) and serum TC and TG, LDL-C content than the A group decreased markedly (P<0.05), between the HC and LC group, the indicators there are statistically significant differences (P<0.05).(3) the liver of A group TC and TG levels significantly elevated compared with N group (P<0.05); HC and LC groups TC, TG content than the A group decreased markedly (P<0.05), between the HC and LC group, the indicators there are statistically significant differences (P<0.05).(4) the A group of bcl-2mRNA expression in liver levels significantly lower than N groups (P<0.05) and the expression of bax mRNA levels significantly lower than N groups (P<0.05); Comparison between HC and LC group, the indicators there are statistically significant differences (P<0.05). Conclusions:Camellia chrysantha by increasing the content of SOD and MDA accumulation reduction, increase bcl-2and reduced expression of bax mRNA levels, slow down liver apoptosis, delaying the senescence of organism; And may by regulation of blood lipid, lower TC, TG, LDL-C, increased HDL-C content, slow down liver cell apoptosis, increase the activity of liver cells and reduce the fat accumulation in liver, to reduce the risk of atherosclerosis in the aging process.