Efficacy Analysis Of CALLG2008Protocol In Treatment Of33Cases Of Adult With Acute Lymphoblastic Leukemia

【Background】Acute lymphoblastic leukemia（ALL）is a group of neoplastic diseaseoriginated in lymphoid progenitor cells which is more common in children andcan occur at any age. ALL is a hematological malignancy with highheterogeneity and its therapeutic regimen should be varied according todifferent patients. Within the past25years, the therapeutic efficacy ofchildhood ALL has been improved continuously, of which long-termdisease-free survival（DFS）can be up to80%. On the contrary, the therapeuticefficacy of adult ALL remains poor, of which long-term DFS is about35%.Accordingly, to improve the efficacy of adult ALL, extend the remission, andmake the patients obtain long-term DFS become the common goal of thehaematologists at home and abroad.【Objective】CALLG2008Protocol is an overall program about sequential chemotherapyfor adult ALL which is established by Collaborative Group of adults with acutelymphoblastic leukemia. It is emphasized that comprehensive treatment ofadult ALL according to risk stratification is rather important. The therapeuticefficacy of CALLG2008in the treatment of adult ALL will be assessedobjectively in this article.【Methods】Strictly collecting the clinical data of>=14years old adult ALL treated byCALLG2008Protocol which were diagnosed in May1,2009to December31,2011in Fujian Medical University Union Hospital by inclusion and exclusioncriteria and making a efficacy analysis.【Results】33cases of ALL patients were enrolled, the CR rate was up to93.9%, and the total response rate was97%. There were no severe toxicities that were outof control, and no early deaths were observed. The overall survival （OS）at1year was only55.4%which was lower than other similar studies abroad. At thesame time, the relapse rate (43.8%) and the1-year mortality (48.5%) werehigh. It may be related to not enough follow-up time and patients who were notobedient and without enough economical support. The risk factors analysisshowed that WBC level in newly diagnosed patients may influence the OS andrelapse-free survival（RFS） of ALL. Influence of age, immunophenotype andcytogenetics on prognosis in ALL had not been confirmed in this study. Thereason may be there were fewer cases and not enough follow-up time.【Conclusion】CALLG2008Protocol to adult ALL has a high remission quality and nosignificant infection rate nor mortality rate during the induction. The DFS needsto be observed longer. It is essential to carry out MRD monitoring to determinethe early recurrence and whether or not to intervene which is important toconsolidate and improve the long-term efficacy.