The Changes And Significance Of Serum25-hydroxyvitamin D₃in Newly Diagnosed Diabetes Mellitus And Diabetic Kidney Disease Patients

Objective Recently, as the affector of diabetes mellitus，vitamin D has attracted muchattention and become a new domain. Increasing observational and interventionl studies haveprogressively clarified the relationship between vitamin D and diabetes mellitus, and thoroughlyresearched the mechanism, however, there are problems to be solved. Through the determination ofserum25-hydroxyvitamin D₃to understand the content of vitamin D status， we analysed thechanges of serum vitamin D₃in different populations to investigate the association of vitamin Dwith newly diagnosed type2diabetes （T2DM） and diabetic kidney disease （Diabetic kidneydisease, DKD）.Methods Patients were divided into three groups including52cases of T2DM,53cases ofDKD and50cases of normal glucose tolerance （NGT） in the study. The indicators of25-（OH）D₃,BUN, Cr, PTH,24-hour urine protein were measured. The level of serum25-（OH）D₃wasexamined by enzyme-linked immunosorbent assay（ELISA）. The β-cell secretion function andinsulin sensitivity were assessed by HOMA-βand HOMA-IR.Results The level of serum25（OH） D₃decreased with developmental procession of T2DMpatient from NGT to DKD, and vitamin D negatively correlated with HOMA-β （r=-0.34, P=0.03）and Cr （r=-0.32, P=0.04）. Comparison with NGT group, the level of HbA1c increasedsignificantly （p <0.05）, whereas the valuation of HOMA-β and25-（OH） D₃decreased significantly（p <0.05） in T2DM group. Compared to T2DM group, the indicators of age, duration, systolicblood pressure,24h urine protein, BUN, Cr, PTH and others showed a significant increase （p<0.05）. in contrast, the level of HbA1c, HOMA-β,25-（OH）D₃suggested a significant decrease （p<0.05） in DKD group.Conclusions The data suggested that Vitamin D deficiency is correlated with diminishedβ-cell function in T2DM patient and the progression of DKD. In order to reduce the risk ofdiabetes and its complications, clinically, it is necessary to supplement the amount of vitamin D inpatients at high risk of diabetes.