Study On Growth, Development And Aging Of Splenium Corporis Callosi In Normal Person:Assessment With Diffusion Tensor Imaging Technology

Objective: To quantify the parameters of MRI diffusion tensor and the quantity offiber bundle changes of normal splenium of corpus callosum with advancing age, andto reflect the callosal structure changes with growth, development, and aging by usingdiffusion tensor imaging (DTI). Methods:266persons with normal head (M133,F133,2months-85years) were classified into ten groups according to their ages:Group1(≤1year old); Group2(2-3years old); Group3(4-6years old); Group4(7-12years old); Group5(13-18years old); Group6(19-29years old); Group7(30-39years old); Group8(40-49years old); Group9(50-59years old)and Group10(≥60years old). And they were all enrolled and underwent conventional magneticresonance imaging (MRI) and diffusion tensor imaging (DTI) respectively.Postprocessed the DTI source data: measure the FA and ADC value on spleniumcorporis callosi. DTT was utilized to track white matter fiber. Results:(1)There wasno significant statistical difference in FA or ADC value of splenium corporis callosibetween cerebral hemispheres or between genders.(2) FA value of splenium corporiscallosi was keeping rise with advancing age until50years old, while the ADC value isopposite.(3) There was significant statistical difference in fiber bundles of spleniumcorporis callosi between genders. However, the quantity of the white matter fibers onsplenium corporis callosi were increased with advancing age no matter male or female,and the tend of its change is approximate with FA value. Conclusions:(1)DTI canreflect the law of growth, development and aging on splenium corporis callosi.(2)Thedevelopment of cerebral white matter in normal splenium corporis callosi have nodifferent between cerebral hemispheres, but would possible between genders.(3)The FA and ADC value measured can be a reference to further research. Objective: To analyse the shape，fiber structure, courser and distribution of spleniumcorporis callosi in normal adult cerebrum by using diffusion tensor tracking.Methods：8healthy adults (4males,4females；age range,25-48years; mean age36.5years)were enrolled and underwent conventional magnetic resonance imaging(MRI) and diffusion tensor imaging (DTI) respectively. All data were transferred topersonal computer and were processed with diffusion tensor tracking by TrackVis(Massachusetts General Hospital, Boston). Results：(1)The fibers morphosis of thewhole corpus callosums were well displayed when reconstructed in center sagittalview．(2) The tracking lines in the splenium of the corpus callosum were clearlydistinguished into two type by optic radiation, one in the ventral portion were enteredinto posterior temporal white matter (tapetum); The others were in the dorsal portionmainly reached parietal and occipital lobe.(3)We can see a bouncary between thelines in splenium and body of corpus callosum in some case. Conclusion：(1)Diffusion tensor tractography is useful for showing the normal adult cerebral corpuscallosums, and open a new field for researching cerebral white matter fiber in vivo.(2)The tracking lines that crossed through the splenium corporis callosi were mainlyentered into temporal, parietal and occipital lobe, and have important relationshipwith cerebral vision and auditory function.