The Clinical Application Of Different Sequences In Diagnosis Of Cerebral Cavernous Angioma At3.0T MRI

Objective：To investigate the clinical application of different Sequence indiagnosis of cerebral cavernous angioma at3.0T MRI.Materials and methods：We retrospectively analyzed the results of95patientswith cerebral cavernous angioma who were confirmed by MRI orpathological diagnosis.（57male，38female，age range2-84years，average age45.13土19.52years,80solitary cases,15multiple cases）.All patients were used MRscan，including T1WI、T2WI and SWI scan.41cases were used contrast enhancementscan,10cases were used3D-TOF MRA scan.18cases were confirmed bypathological diagnosis.The location of lesions and clinical symptoms were analyed.Tocompared the numbers of cerebral cavernous angioma used blind method.Thesizes,forms，signal charcteristic of cerebral cavernous angioma were analyzed. χ2test were used on the number of lesions of different sequence.Analysis of ariance（ANOVA）were used of lesions sizes between different Sequence.There weresignificant difference with statistic analysis (P<0.05).Results:1.T1WI can detect77lesions among80solitary cases of CCA,T2WIcan detect80lesions,DWI(n=79) can detect79lesions, dark-fluid (n=77) can detect76lesions,SWI can detect80lesions; T1WI can detect84lesions among15multiplecases of CCA,T2WI can detect100lesions,DWI(n=14) can detect121lesions,dark-fluid(n=14) can detect lesions and SWI can detect210lesions.2.On T1WI,41lesions displayed isointense or hypointense among80solitarycases of CCA,22lesions displayed hyperintense,17lesions displayed mixed signal,9lesions displayed hypointense on the brink or “hoop sign”;On T2WI,10lesionsdisplayed hypointense,28lesions displayed hyperintense,42lesions displayed mixed signal,52lesions displayed hypointense on the brink or “hoop sign”;On DWI(n=79),59lesions displayed hypointense,20lesions displayed inhomogeneous lowsignal with high signal;On SWI73lesions displayed hypointense,7lesionsdisplayed inhomogeneous low signal with speckles,patchy high signal. OnT1WI,22lesions displayed hypointense among15multiple cases of CCA,14lesionsdisplayed hyperintense,48lesions displayed mixed signal,126lesions displayedisointense; On T2WI,30lesions displayed hypointense,20lesions displayedhyperintense,50lesions displayed mixed signal,110lesions displayed isointense,53lesions displayed hypointense on the brink or “hoop sign”; On DWI(n=14),109lesions displayed hypointense,12lesions displayed inhomogeneous lowsignal with high signal;On SWI,180lesions displayed hypointense,30lesionsdisplayed inhomogeneous low signal with speckles,patchy high signal.41cases of after administration of contrast media,31lesions had no enhancement,5lesions slight enhancement and5lesions obviously inhomogeneous enhancement.10cases examined by MRA and all lesions showed no abnormal.3.Cerebral cavernous angioma which accompany with11casesvenous malformation were detectde by SWI,7lesions clear displayed draining veinsand medullary veins,the remaining4lesions clearly displayed draining veins;4lesionsdisplayed draining veins on T1WI, the remaining7lesions unclearly displayed;4lesions displayed draining veins on T2WI, the remaining7lesions unclearly displayed;4lesions displayed draining veins on DWI, the remaining5lesions unclearlydisplayed.Conclusion:1. SWI detected and displayed cavernous angioma lesions andassociated with venous malformations has good application value.2. DWI can detect more lesions of cavernous angioma than T1WI, T2WI anddark-fluid.