Analysis Of Clinical Feature And Correlation Factors Of Prognosis Of Cervical Adenocarcinoma

Objective:Investigate the clinical and pathological characteristics of cervical adenocarcinoma, and further analysis of prognostic factors.Methods:Retrospective analysis in January2002to2011in December Obstetrics and Gynecology, First Affiliated Hospital of Fujian Medical universty diagnosis and treatment of62cases of cervical adenocarcinoma in patients with clinical follow-up data. Analyze and summarize the clinical and pathological features and prognostic factors.Results: Cervical adenocarcinoma incidence average age of43.34±10.28years; vaginal bleeding as the main symptoms accounted for79.03%(49/62), followed by vaginal discharge accounted for29.03%(18/62), the two can co-exist; cervical localcauliflower-shaped, barrel, ulcers, erosive change accounted for35.7%,32.9%,12.9%and4.3%; pathological type was pure mucosal adenocarcinoma50.0%(31/62), small cell neuroendocrine carcinoma was12.9(8/62), mucinous adenocarcinoma,9.7%(6/62), papillary adenocarcinoma was9.7%(6/62), adenosquamous carcinoma8.1%(5/62), clear cell carcinoma was4.8%(3/62), uterineendometrial adenocarcinoma, minimal deviation adenocarcinoma and cervical stromal cell tumors account for1.6%(1/62).The5-year survival of cervical adenocarcinoma in this group was22.22%. Univariate analysis, FIGO stage, depth of myometrial invasion, lymph node metastasis, tumor size, ovarian transposition or not, blood loss and perioperative blood transfusion and cervical adenocarcinoma, survival was significantly (P<0.05), age, histological grade and before and after surgery combined with radiotherapy/chemotherapy and the survival rate was significantly correlated (P<0.05). And survival was significantly related factors included in the Cox risk model regression analysis, FIGO stage, depth of myometrial invasion, lymph node metastasis, tumor size and ovarian transposition and the survival rate was significantly (P<0.05) Cervical adenocarcinoma, FIGO stage II period, with lymph node metastasis, tumor diameter≥4cm breakthrough deep myometrial invasion and not preserving ovarian its five-year survival rates were significantly lower than FIGO stage I period without lymph node metastasis, tumor diameter<4cm, depth of invasion within the superficial muscle interstitial and preserving ovarian (P<0.05).Conclusions: This group of cervical adenocarcinoma vaginal bleeding and (or) vaginal discharge was the main symptom. The main pathological types of cervical adenocarcinoma were pure mucosal adenocarcinoma, small cell neuroendocrine carcinoma, mucinous adenocarcinoma, papillary adenocarcinoma, adenosquamous carcinoma, clear cell cancer, and so on. Approximately18.33%is inconsistent with the pathological diagnosis of cervical adenocarcinoma preoperative biopsy.5-year survival of cervical adenocarcinoma in this group is22.22%. FIGO stage, lymph node metastasis, tumor size and depth of myometrial invasion may be important factors for the prognosis of cervical adenocarcinoma. The shift to retain ovarian surgery may not increase the risk of early stage cervical cancer prognosis.