Study Of The Effective Orifice Area (EAO) After Aortic Valve Replacement

Objective To find the rules and reasons of the effective orifice area(EOA) change after aortic valve replacement.Methods From January2006to December2006,85patients(7patient out of85was lost in the review) with aortic disease, who underwent aortic valve replacement only. Measure EOA at the time of1week,6months,1year,3years, and5years after aortic valve replacement by transthoracic color Doppler echocardiography. To find the rules of the EOA change and analysis of the reason leading to the change.Results All78patients, the EOA tended to decrease gradually, with the increasing pressure gradients across the aortic valve. For the21mm prosthesis of GK-2、Carbo、 St.Jude and the bioprosthesis, the EOA are2.04±0.07cm2and1.89±0.10cm2(P<0.001)、1.50±0.17cm2and1.29±0.20cm2(P<0.001)、1.29±0.27cm2and1.15±0.29cm2(P=0.03)、1.98±0.11cm2and1.99±0.01cm2(P=0.83) at the time of1week follow-up and5years. Rather than2.36±0.15cm2and2.17±0.18cm2(P<0.001)、1.94±0.21cm2and1.62±0.37cm2(P<0.001)、1.93±0.24cm2and1.65±0.25cm2(P<.001)、2.32±0.15cm2and2.17±0.06cm2(P=0.16) for the23mm prosthesis.Conclusion The EOA tended to decrease gradually, it is relate to the type of the prosthesis, the bioprosthesis had nearly no change. And we find that it is nearly no correlation between the age, gentle,Body mass Index (BMI), anticoagulation level (INR) and the EOA change;the GK-2double leaflet valve had little change, and the Carbomedics Std and St.Jude Std had obvious change; It may due to the different prosthesis and biocompatibility to the human body, which leads to different proliferation-like change.