The Protective Effects And Mechanisms Of Geniposide On Bronchial Asthma In Mice

In this study we established an OVA-sensitized and-challenged BALB/c allergic asthmamodel to explore the protective effects of Gen in the non-infectious inflammation reactions ofairway and investigate its possible mechanisms. According to the findings, Gen (80mg/kg) canmarkedly improve the OVA-challenged hallmarks of asthma including reduction of eosinophilinfiltration into pulmonary tissues in BALF as well as the total amounts of inflammatory cells,down-regulate the levels of Th2-associated cytokines (eg. IL-4, IL-5, and IL-13) and eotaxin inBALF, ameliorate the pathophysiological symptoms around bronchia and OVA-driven airwayhyperresponsiveness. Collectively, These findings revealed that Gen exerted beneficial effects onOVA-induced asthma probably through the suppression of NF-κB signal transduction, whichprovided theoretical and statistical evidences suggesting that Gen can be treated with asthma andseveral other diseases and may be applied in researches and developments of some relative drugmaterials.