The Research Of Feasibility Of Cu-IDM Used As Active Matter In Intrauterine Device

The traditional Intrauterine Device（IUD）mainly through the trestle structure andrelease the active material of copper ions to achieve contraceptive effect, and throughloading the drug of Indomethacin (IDM) in IUD to reduce the side effects of IUD byreleasing the active material of IDM to diminish inflammation bleeding,In this article, the crystallization method was used to synthesis the complexescopper-indomethacin(Cu-IDM) with IDM and water copper acetate in ethanol as thesolvent. And the synthesis process and the post-processing technology was researched andthe physicochemical property of Cu-IDM was characterized, which was used to provethe Cu-IDM can be used in IUD as the active substance to release copper ions and IDM.In the synthetic technology of Cu-IDM research, we got the optimal synthetic processby researching the influence of the raw material ratio, the reaction temperature and thereaction time in the production rate. And the experimental results show that the yield ofthe Cu-IDM can achieve optimal with the ratio of raw materials for2:1.1, the reactiontemperature for50℃and the reaction time controling in about30h. Through research onthe post-processing to optimize the product purity technology, and the experimentalresults show that in the post-processing the amount of water and ethanol, the washing timeand the order of washing influence the purity and stability of Cu-IDM. The feedstockremaining after reaction can be removed by washing twice with water, and then washingfour times with ethanol to get the product with high purity. The Cu-IDM will unstablewhile increaseing the amount of water or using ethanol first, which will reduce the purityof the product.The organization structure and the physicochemical property of Cu-IDM wascharacterized by1H-Nuclear magnetic resonance, X-ray diffraction, scanning electronmicroscopy, differential scanning calorimetry and thermogravimetric analysis. By1H-NMR results show that we successfully synthesized Cu-IDM by IDM. And through theXRD we know that Cu-IDM for tricinic crystal. SEM results show that Cu-IDM for3arrisbody structure, and the size is about1μ m. The DSC results show that the melting pointrange from160.7to177.5℃. The TG results show that before165℃Cu-IDM hasdehydration reaction, and the coordinate bonds between Cu and IDM are unchanged. The gravimetric analysis was used to get the the solubility of Cu-IDM in simulationof uterine liquid (SUS) and water. Use the result and combined with uv-visible method tostudy decomposition performance of Cu-IDM in SUS, which verifies the applicationfeasibility of Cu-IDM in IUD. Uv-visible method was used to study the solubility ofCu-IDM in two organic solvent acetic ester and acetonitrile. The results show thatCu-IDM is more soluble in ethyl acetate than acetonitrile. Considering the toxic of organicmatter, acetic ester can be the solvent when use straight dipping process to load Cu-IDMin IUD.