The Studies On Synthesis And Characterization Of Flavonoids Schiff-base Ligands As Aluminum And Zinc Ion Fluorescent Sensors

Flavonoids have low toxicity and broad spectrum of pharmacological activity, have become the hotspot of the nature of drug research and development at home and abroad, and have broad prospects. Schiff-base have been of concern, because N atoms in the C=N group have one lone pair electron, given the significance of its chemical and biological. The Schiff-base is a very important class of ligands, and its synthesis is relatively easy. It can be obtained different structure of the Schiff-base ligands from single tooth to polydentate.Aluminum is the most abundant metal element in nature. As the existence of aluminum is in the form of free aluminum ions, the excessive aluminum ion accumulated in organisms can cause various diseases. Zinc ions play a vital role in nature and biological systems. The content of zinc ions in the human body is second only to iron ions, and their normal concentration range from the sub-nM to0.3Mm. In a variety of biological systems such as gene expression, protein conversion and neurotransmission, zinc ions play an important role. The destruction of the intracellular concentration of zinc ions, will lead to the occurrence of a range of diseases, such as Alzheimer’s, epilepsy and infantile diarrhea. Therefore, the design of the fluorescent probes to detect the aluminum ions and zinc ions has attracted much attention from researchers in recent decades.In this paper, we design and synthesis two aluminum ion probes and one zinc ion probe. The three probes are7-methoxychromone-3-carbaldehyde-(3’,4’-dimethyl)pyrrole hydrazone (MCPH)7-methoxychromone-3-carbaldehyde-(2’-benzothiazolylthio) acetic acid hydrazone (MCAH),7-methoxychromone-3-carbaldehyde fluorescein hydrazone (MCFH) respectively. These three probes have low detection limit and good selectivity. We believe they can provide a new direction of the studies on aluminum and zinc ion probe.