Studies On Syntheses Of Natural Products6-Hydroxypunctaporonin E And Migrastatin

This dissertation is on the studies of the syntheses of6-Hydroxypunctaporonin E and Migrastatin. It consisted of the following three parts:Chapter1. Asymmetric organocatalysis in natural product syntheses (Review)This review summarizes the applications of asymmetric organocatalysis in natural product syntheses.Chapter2. Studies on the synthesis of natural product6-Hydroxypunctaporonin EWe design a synthetic route which features a Diels-Alder reaction as key step. And the desk studies on the synthesis of natural product6-Hydroxypunctaporonin E by this route were described.Chapter3. Studies on the synthesis of natural product MigrastatinThe precursors of esterification were accomplished from croton aldehyde by an epoxide opening reaction by1,3-dithiane carbanion, a Horner-Wadsworh-Emmons reaction, an aldol reaction as key steps, which give foundation for the total synthesis of natural product Migrastatin.