Study On Improvement Of Production Of Tibolone Tablets

Menopausal syndrome can cause a series of clinical symptoms that isdue to a decline in estrogen levels. It is an natural phase that Each womanwill be experienced In their lives.Not only bring much trouble tomiddle-aged and old women,and seriously affects their physical anmentalhealth as well as quality of life.Tibolone can effectively improve thesymptoms of menopausal women who is lack of estrogen. Tibolone is Widelyused in the treatment of climacteric syndrome. Because of the materialinstability problems exist in original recipe,the quality of the productis affected and increased the adverse reactions ofpatients.Therefore,this paper was carried out for drug prescriptionoptimization and the modification of product prescription.The new excipient and process prescription is determined by means ofthe raw materials compatibility test.The new prescription using thepowder tabletting technology directly,the production of tibolonetablet’s quality fully conforms to the standard requirements,and makethe production process more simple.Through the stability test,productprocess is stable, the related substances is always in a reasonablerange.At the same time, make the product solubility increased, so thatthe product quality further improved.The process improvement reduces the production costs, improved productquality, and improve the economic benefit.