Research On Three-Component Coupling Reactions Catalyzed By Cu Nanoparticles

Since the formation of the concept of nano-materials in the early1980s,nano-materials has received considerable attention by countries around the world.Simultaneously, nano-materials science is becoming a booming high-paying technology.Over the past decades, literatures about preparation, nature, application of nano-materialshas been widely reported. Since nanoparticles have large surface area, high tables surfacelattice defects, and high surface energy, the catalytic activity and selectivity of catalyst aremuch higher than traditional catalysts. This thesis contains the following three parts:1. One-pot copper nanoparticle-catalyzed synthesis of1,4-disubstituted-1,2,3-triazolesin water.Three-component reaction of halides, sodium azide and alkynes in water Catalyzed byCu-nanoparticles afforded1,4-disubstituted-1,2,3-triazoles in exclusive regioselectivity andmild reaction conditions.The method is efficient and environmentally friendly.Cu-nanoparticles can be easily prepared.2. One-pot copper nanoparticle-catalyzed synthesis of imidazo[1,2-a]pyridines undersolvent-free ConditionsA highly efficient catalyst, Cu nanoparticles, was investigated to catalyze three-componet coupling reaction of2-aminopyridines, aldehydes and alkynes. It gave thecorresponding imidazo[1,2-a]pyridines in good to excellent yields under the solvent-freecondition and besides, operation is simple, and afford compounds containing imidazole andpyridine structure by one step.3、Solvent-free one-pot reaction of CuI nano-catalysis synthesis of propargylamines An efficient CuI nanoparticles catalyzed three-componet coupling reaction of a ketone,an alkyne, and a primary amine is described. The catalyst system is better adaptability tothe substrate, and the amount of catalyst is low.