| Tinea pedis is common and stubborn skin disease, spread through contact, high prevalencerate, and the high infection rate. If not treated can cause other disease, affecting people’s workand life. Western medicine agents at home and abroad to treat tinea diseases mainly includechemical agents and broad-spectrum antifungal agent. The broad-spectrum antifungal agents,there is the risk of abuse clinically, and side effects. Patients choose external chemical class ofantifungal agents in the treatment of. Through the analysis, the domestic chemical class ofantifungal agents, the lack of compound preparation of different types of chemical mechanismcomponents. So we think it is necessary to improve the existing preparation, new formulation,new synergistic agent and dosage form to improve quality level of preparation. The surveyfound that the "AFAKIN" products is more prominent, this topic for research on prescription,the original prescription after dismantling and reorganization, the undecylenici acid andsalicylic acid in compound components, with two ethanol as the new prescription synergist,named Salicylic Acid and Undecylenici Acid Solution.Through the investigation and stability study of pharmacodynamics experiment, quality,confirmed the Salicylic Acid and Undecylenici Acid Solution produce more than the"AFAKIN" effect. On the basis of the quality and stability of the results, strictly abide by therequirements of continuous production process, the three batch of Salicylic Acid andUndecylenici Acid Solution spray in the GMP workshop (each batch of10000bottles). Afterthe test verification of QA department and QC department, production technology and productquality are in line with the requirements of. |
PDF Full Text Request