Synthesis And Paclitaxel Release Of Polyether-Anhydrides Prepared With UV-Curing Process

The polymers used for drugs controlled release system need to have better biocompatibility, processability and mechanical properties, so that the polymer can meet a variety of special requirements for drugs controlled release system. Therefore, the design and synthsis of polymer materials for drugs controlled release system is important, which has absorbed tremendous attention. By modifying the polymer materials and their derivatives, many new polymer materials, which have good mechanical properties and processing performance, have been able to provide a stable drug compatibility and drug release environment.Polyanhydrides are the polymeric products of the dehydration of diacid molecules. Polyanhydrides are unstable due to the hydrophobicity of anhydride bond. But the drugs release controlled by polyanhydrides shows a zero-order kinetics attributed to the surface erosion degradation behavior. The synthesis and modification of polyanhydrides has been a hot issue. Currently, a variety of polyanhydrides have been synthesized and their physicochemical property, biocompatibility, drug controlled release properties and drug release mechanism are being researched.Polyanhydrides can be synthesized by various techniques, such as melt polycondensation, ring opening polymerization, interfacial condensation, and so on. But a high vacuum and high temperature condition is needed, so that the high molecular weight polyanhydride can be achieved. In order to develop a simple, economical and rapid approach to synthesize polyanhydrides, we prepared a series of polyether-anhydride membranes composed with different mass fraction of sebacic acid, polyethylene glycol dimethacrylate and poly(tetramethylene oxide) dimethacrylate by ultraviolet curing process.The chemical structure and thermal properties of target polyanhydrides were characterized by FT-IR, DSC and XDR, while the paclitaxel releases from the polymer matrix were evaluated by HPLC. The results demonstrated that the UV-curing process is a good method to synthesize the target polymers in a short time, and the paclitaxel release procedure can be controlled by changing the component in the copolymers.