Study On The Synthesis Of Faropenem

Faropenem was developed by Suntory&Co., Ltd, and it is carbapenems with the replacement of tetrahydrofuran at C-2position. It shows broad and potent antibacterial activity by combining with PBP-2of bacterials to restrain the synthesis of the cell wall of bacteria. Faropenem is stable to most β-lactamase as well as DHP-1. It has potent antibacterial activity towards kinds of anaerobe and aerobe. Faropenem came into market in1997in Japan.Faropenem was synthesized through7-step reaction which was started from (3s,4r)-4-acetoxy-3-[(r)-1-(tert-butyldimethylsilyloxy) ethyl] azetidin-2-one. Several recrystallization conditions were researched and pure product were obtained. The method was simple, and the yield and purity of the product were good. The method was suitable for industrial production. The total yield is35.0%.All products were characterized by modern analytical methods including UV, IR and ’HNMR.Through the new synthetic route of Faropenem, the producing procedures were simplified and the yields and purity of intermediats were improved. At the same time, it cuts down the cost and diminishes environmental pollution. All of these provide the theoretical and experimental evidence for industrial production of Faropenem.