Preparation And Characteristics Of Inorganic Nanometer Partical Doped Carbon Nanofibers

Carbon nanofiber fabricated via electrospinning combined withcarbonation method, with favourable chemical stability, propermechanical properties, similar structure of natural extracellularmatrix(ECM), hight porosity and specific surface area, is superiorcandidate scaffolds for tissue engineering applications. To overcome theinertness of carbon nanofiber and improve the compatibility with tissuedefects, many researchers focused on preparation of compositesbiomaterials consist of carbon nanofiber and other kinds of biomaterials.The composite cabon nanofiber, containing calcium phosphate orbio-glass, was obtained by using sol-gel method combined withelectrospinning and in situ sintering. This composite nanofiber shows thegood biological compatibility, decreasing length-diameter ratio with theinorganic nano-particles degradation, which definitely contribute to theeliminating of carbon nanofiber. Consequently, the new carbon nanofibercontaining the inorganic nano-particles, with well biocompatibility andhigh mechanical strength, can be used in bone repair. In this thesis, bioglass(or β-TCP)@carbon nanofiberwas gained onthe basis of our early research, and the biological performance of thenanofiber with different addition of silicon oxides(or the doped ion) wassystematically evaluated. Inorganic particles in nanoscale could be seenclearly on the fiber surface by SEM and throughout the fiber by TEM.Biological mineralization results show that the optimal content of siliconoxides was around68mol%.Osteoblasts MC3T3-E1in vitro co-cultureexperiments revealed that the optimal content of silicon oxides wasaround68mol%, and the introducing of Mg~2+and Zn~2+definitely improvethe bioactivity and biocompatibility of β-TCP@carbon nanofiber.Therefore, the new carbon nanofiber with different inorganicnano-particles can be directly used in bone tissue engineering. And thiscomposite is also ideal reinforcement for other scaffold, which fabricatedvia phase separation technique, to repair the weight bearing bone defects.