Phase-Transfer-Catalyzed Cyclization Of Propargyl Compounds For Synthesis Of Indene Derivatives And Disubstituted Benzo[b]Furans

In this paper, the thesis aims at the studies on the transition-metal/PTC catalyzed alkynes cyclization reactions.lt mainly consists of the following two partsPart â… :Summarized the more recent progress in alkynes cyclization reactions. According to the reaction processes, we classified them in three types1) Pd-catalyzed alkynes cyclization reactions2) Ni-catalyzed alkynes cyclization reactions.3) Au/Pt-catalyzed alkynes cyclization reactions.4) Non-metal-catalyzed alkynes cyclization reactions. In this review, we introduced their applications in the synthesis of carbocyclic and heterocyclic compounds respectively.Part â… :Phase-Transfer-Catalyzed Intramolecular Cyclization of Propargyl Compounds for Synthesis of Indene Derivatives and Disubstituted Benzo[b]furans we have demonstrated for the first time that phase-transfer-catalyzed cyclization of propargylic compounds is a novel and efficient method for synthesis of allenyl indene derivatives and disubstituted benzo[b]furans. These reactions are run under mild conditions, tolerate various functional groups, and generally provide the desired products in moderated to good yields. Compared to the expensive transition-metal catalyzed reaction, the process showed considerable synthetic advantages in terms of mild reaction condition, environmentally friendly and low cost.