In this thesis, the alkoxycarbonylation of epichlorohydrin in the presence of Cobalt-based catalyst was investigated. A series of reaction conditions has been studied, in order to abtain a gentle, highly efficient novel catalytic system for alkoxycarbonylation, and the results are satisfactary.1. With Co2(CO)8as the main catalyst, the system examines the different conditions of chiral epichlorohydrin carbonylation reaction, to synthesize the important use of optically active4-chloro-3-hydroxylbutryrate, and in the reaction process, no racemization of the substrate take place, and the steric configuration of products is the same as that of epichlorohydrin, we can achieve98.5%conversion rate of chiral epichlorohydrin and80.3%product selectivety of4-chloro-3-methyl-hydroxylbutryrate, and product on the enantiomeric excess (ee) was higher than99.9%. On this baise, we also made a corrresponding research on epichlorohydrin ethoxycarbonylation.2. A series of dialkylimidazolium, N-arylimidazolium based tetracarbonylcobaltate ionic liquids and metal complexes of salen type tetracarbonylcobaltate anion were designed, synthesized and characterized, which results laid the foundation for the design and synthesis of different cobalt corbonyl complexes. On this basis, the salen type tetracarbonylcobaltate anion complexes catalyzed alkoxycarbonylation of epichlorohydrin to synthesis of4-chloro-3-hydroxy-methylbutyrate was explored. Epichlorohydrin conversion and product selectivity have abtained good results. |