Access To Indoloquinolizidines Through Organocatalytic One-Pot Reactions Utilizingα-oxo-Butyrolactam As Pronucleophile

1,2-Dicarbonyl derivatives have been utililized in organic synthesis more and more commonly. They could be easily used in sequential transformation due to the more reaction centers than others. In the past, most efforts have been taken in the research of the increased electrophilic ketone reactivity by the presence of an adjacent carbonyl. However, the research of its nucleophilic potential is in its infancy. In the near future, research in this aspect will play an important role in the research field of1,2-dicarbonyl derivatives.Synthesis of compounds containing many chiral centres is one of the hot toptics in organic synthesis. Especially in natural product synthesis and exploitation of useful synthetic scaffolds,"one-pot" strategy has attracted more and more concern. Complex scaffolds could be constructed readily by this strategy in the form of simple process of purification and protection route with less money and time cost.