Study Of Three-dimensional Magnetic Resonance Thermometry Method

As the increasing requirement of cancer management and the life quality, thenon-invasive or minimally invasive therapy with the smaller trauma and faster recovery thantraditional open operation becomes more and more popular. Most of the traditional cancertreatments have been transferred from the open invasive surgery to non-invasive or minimallyinvasive treatment. Tumors thermal therapy as a good noninvasive method becomes important.Compared with the other imaging modalities, magnetic resonance imaging (MRI) has manyadvantages: non-invasive, no ionizing radiation, excellent soft tissue resolution, arbitraryorientation imaging. Furthermore, it can accurately display the functional response to thehyperthermia, and can combine the real-time imaging of anatomical and the temperatureimages. Therefore, MRI has become one of the best means for guidance and monitoring theimage guided minimally invasive treatment.The big feature of Magnetic Resonance thermometry is that the technology can map thetemperature during hyperthermia through quantification the change of those parameters.Meanwhile, MRT can also output the anatomical image. The development of real-time andaccurate MRT technology is significant for the efficacy and safety of magnetic resonanceimaging guided thermal therapy.After discusseing and researching the MRI thermometry method and summarizing thetwo-dimensional of the magnetic resonance thermometry method, this thesis proposes thetwo-dimensional of the magnetic resonance thermometry method. The main work is describedas follows:Firstly, after mainly introduced the development of tumor technology and its main way,this thesis overview the principle and advantages of magnetic resonance imaging from thespin, RF pulse and resonance and relaxation time, etc.Secondly, after studied scan parameters and processing parameters of the magneticresonance imaging, including the choices of canning sequence, TE, echo phase matchingmethod, the order of fit polynomial and the area of ROI_fitting and ROI_fitted, we given atheoretical analysis and conclusions in-depth study the two-dimensional temperature imagingmethod.Finally, based on high spatial correlation of phase among slices in a3D slab, we proposethe three-dimensional temperature quickly imaging methods. Compared with standard sliceby slice three-dimensional method, our method saves about triple data processing times.In-vivo normal temperature experiments, the phantom and ex-vivo animal organs heating experiments with a MRI compatible high intensity focused ultrasound platform wereconducted on a Magnetom Siemens TIM Trio3T system and we compare the new methodproposed by the thesis and the slice by slice method.