Model-based Analysis Of The DBS Mechanism On Basal Ganglia

Parkinson’s disease (PD) is a neurodegenerative disease affecting the olds’health seriously. The biological cause and treating mechanism of PD, which are challenges in neuroscience, have not yet been fully elucidated. Modern neuroscience research results show that, the basal ganglia (BGS) have been implicated in movement control, motor and cognitive sequence generation, sequence encoding and action selection. The pa thological changes of B GS will l ead t o t he ge neration of P D. A neuronal population model of the subthalamic nucleus-globus pallidus in BGS is established in our studies. The pathogenesis of PD and the mechanisms of deep brain stimulation (DBS) are also analyzed.First of a ll, based on the latest st udies about neuroanatomy, we propose a neuronal population model of t he s ubthalamic nuc leus-globus pa llidus, w hose complex dynamical behaviors are investigated. It’s found that the model can simulate the physiological and pathological activities of BGS. The bistable state of the model represents physiology activity, and the oscillations c onsisting of bursts of high-frequency activity stand for pathological activities.Two pathological patterns of the subthalamo-pallidal complex are created, which are caused by an increase in striato-pallidal inhibition and a weakening of intrapallidal connections. The dynamics of BGS in two Parkinson’s patterns during DBS have been studied. I t’s f ound t hat the efficacy of D BS i n que nching the pa thological oscillatory activity depends on the DBS parameters.In view of the diversity of the target nuclei in PD during DBS, We investigate the network effects of DBS for PD in different target sites in the subthalamic nucleus (STN), the globus pallidus pars interna (GPi), and the globus pallidus pars externa (GPe) based on the population model. The mechanism of action of DBS is discussed and a novel hypothesis,“Inhibition- excitation network mechanism”,is proposed.The results of our paper provide a framework for the studies of the biological cause of PD, and also a guidance of selecting DBS parameters in clinical medicine.