| Objective：To explore the genetic association between the single nucleotide poly-morphism (SNP) of Survivin gene and the susceptibility to bladder cancer amongChinese Han people.It will provide clinical guidance to implement the individualprevention and early dianosis and treatment of the susceptible population of effectiveand trageted bladder cancer.Methods：The association between the2survivin SNPs and bladder cancer suscep-tibility and progression was investigated by PCR-RFLP in115patients with bladdercancer and166healthy controls.We analyzed the relationship between two sites withdifferent genotypes and the susceptibility of bladder cancer using Chi-Square testand Multiple Logistic Regression analysis.Results：For the survivin C-31G polymorphism, individuals with G/G genotype sig-nificantly decreased the risk of developing bladder cancer compared with those har-boring C/C genotype (OR=0.47;P=0.03); Regarding the A9194G SNP, the presenceof the G allele was associated with a significantly reduced risk compared with A allele(OR=0.65;P=0.04).Using the C-A haplotype as a reference, the G-G haplotype wasassociated with a significantly lower risk (OR=0.17; P=0.007).Conclusions：This study confirms the close relationship between survivin gene andbladder cancer. These results indicate that the2SNPs have a significant and coopera-tive influence on bladder cancer susceptibility. |
