| Objective：The Yiqi Wenyang kidney-nourishing method' s function onrespects as thyroid, hypothalamus, serum TRH and pituitary gland TSH of ratswith hypothyroidism was observed through the experimental research, and itsaffection on hypothalamus-pituitary-thyroid axis was also discussed, whichprovides a new thought about hypothyroidism treatment with Chinese medicineand the clinical research information.Methods：This experiment used60Wistar SD rats, and they were dividedinto5groups by random, the contrast group,the model group, the westernmedicine group and the Chinese medicine group (high dose and low dose of QiGui Decoction). In addition to the blank group, the other four groups topropylthiouracil made model2weeks. After12weeks' successful givingcorresponding drug, symptom and condition of every groups rats were observed,and the secretion levels of hypothalamus TRH, pituitary gland TSH and TRH,FT3, FT4, TSH of serum were detected.Result：1.After modeling, the serum FT3, FT4levels were significantly lower thanthose of the blank group (P<0.01), and the TSH level was significantly higherthan the blank group (P <0.01), which determined the success of the modeling.2.After Observing the general state of the hypothyroidism rats before and aftertreatment, the western medicine group and the Chinese medicine different dosegroups had varying degrees improvement. Chinese medicine high and low dosegroup performed excellently than the control group.3.After treatment, comparedwith all treatment groups the serum FT3, FT4level of the modelgroup has statistical significance (P <0.05),compared with the control grouptraditional Chinese medicine high and low dose groups has no statisticallysignificant difference (P>0.05), indicating that the Chinese Medicine high doseand the control group can increase the serum FT3, FT4levels.4. After treatment,compared with each treatment group, the serum TSH level was statisticallysignificant (P <0.01), Chinese medicine high dose group and the control group had no statistically significant difference (P>0.05), compared with controlgroup Chinese medicine low dose group had statistically significant (p<0.05),which showed that Chinese medicine high dose group and control group coulddecrease the serum TSH level.5. After treatment, the level of serum TRH ofeach the treat-ment group had a statistically signi-ficant(p<0.01),compared with the control group Chinese medicine high dose group hadstatistically significant (P <0.05), compared with the control group Chinesemedicine low dose group had no statistical significance (P>0.05),indicatingthat Chinese medicine group and control group could decreasethe level of serum TRH, particularly the Chinese medicine group did.6.TheAfter treatment, we can see, compared with the blank group, thehypothalamic TRH, pituitary TSH level of the model group and the controlgroup had statistically significant(p<0.01). Compared with the blank groupChinese medicine high and low dose group had no statistically significant(p>0.05), and compared with the control group Chinese medicine high and lowdose group had statistically significant(p<0.05), indicating that the Chinesemedicine group could significantly increase the rats' hypothalamus TRH andpituitary TSH levels, and it did better than the control group.Conclusions：1.The Yiqi Wenyang kidney-nourishing method can significantly improvesymptom and condition of rats.2.The Yiqi Wenyang kidney-nourishing method can significantly improvethe rats' thyroid function. It can raise FT3and FT4of the serum and reduce theTSH in it also.3.The Yiqi Wenyang kidney-nourishing method can reduce the TRH in itand raise the hypothalamus TRH and pituitary gland TSH content. |
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