Research On Morphological Damage Effect Of Nan0-TiO₂on Lung Tissue Using Nuclear Analysis Technology

The exposure of Titanium dioxide nanoparticles to the environment can lead to its entering the humanbody by different ways and cause potential damage to health. Respiratory tract is the main way that theparticles outside enter the body. Therefore, the research of TiO₂nanoparticles on the lung injury is veryimportant.This topic selects SD male rats as exposed models. Using optical microscope, transmission electronmicroscope, and synchrotron radiation X-ray absorption fine structure techniques combined with GSH andMDA molecule detection techniques to explore the damage effects of TiO₂nanoparticles on the lung tissue.The main research results are as follows:1．In the chronic toxicology experiment, the morphological damage of lung tissues caused by TiO₂nanoparticles is correlated with its concentration, the affection of TiO₂nanoparticles on the content of GSHand MDA in the lung tissues shows concentration-dependent. With the concentration increases, the contentof GSH reduces(P﹤0.05), the content of MDA increases(P﹤0.05), and the morphological damage ofthe lung tissues is serious, but we can not find nanometer materials in the lung tissues.2．In the acute toxicology experiment, the damage on the morphology of lung tissues caused by TiO₂nanoparticles is correlated with its concentration, the affection of TiO₂nanoparticles on the content of GSHand MDA in the lung tissues shows concentration-dependent. With the concentration increases, the organcoefficient of the lung also increases(P﹤0.05), the content of GSH reduces(P﹤0.05), the content ofMDA increases(P﹤0.05), the morphological damage of the lung tissues is more serious. We can findnanometer materials in the lung tissues, and its content rises with concentration increaseing.