| Fatty liver (FL) is a common liver disease, which is one of the major causesin patients with elevated liver enzymes in developed countries. As metabolicdiseases such as obesity, diabetes mellitus, hypertension, dyslipidemia, havebecome epidemic globally, the prevalence of FL is growing rapidly, and has atrend younger age incidence. The reported prevalence of FL varies based onthe information available in a given population and the diagnostic criteria used.The exact prevalence and incidence of FL are unknown because noprospective studies have been conducted. Therefore, we analyzedretrospectively the health examination data from2006to2010in ThirdHospital of Hebei Medical University, and aimed to explore the prevalence,incidence and the related risk factors of FL in order to provide theoreticalevidence for the prevention and control of the FL in Shijiazhuang, Hebei,China.Part1Prevalence and risk factors of FL of the population inShijiazhuangObjective: To investigate the prevalence risk factors of FL of thepopulation in Shijiazhuang.Methods: In order to clarify the prevalence and risk factors of FL, the dataof7816people received health examination in medical examination center ofthe Third Hospital of Hebei Medical University in2006. The following datewere recorded: gender, age, careers, BMI, blood pressure, white blood cell(WBC), red blood cell (RBC), hemoglobin (HGB), platelet count (PLT),fasting plasma glucose, serum lipid and alanine aminotransferase (ALT).Meanwhile, FL was identified by abdominal ultrasonography observation. Results:1The prevalence of FL and relationship of FL and gender, age, careers:1.1Association of gender with FL: Among the7816subjects,1862(23.8%)were diagnosed as FL. The prevalence in males was significantly higher thanthat in females (32.7%vs.14.8%, P=0.000).1.2Association of age with FL: The total prevalence of FL increased withage growing (P=0.000), the rates of FL in the people of≥40years vs.<40years were16.7%vs.27.3%, there is no significant difference in male peoplein the above groups (30.7%vs.33.5%, P=0.092).1.3The prevalence of FL in various careers: The prevalence of FL were31.7%,27.5%,24.9%,22.4%,22.4%and20.9%in officials, scientificresearchers, office workers, teachers, medical staff and other enterprose staff,respectively. After stratification by sex, there was significant difference in theprevalence of FL for males among different careers (χ~2=36.723, P<0.001), thehigher rate were in officials (39.1%), medical staff (38.7%) and office workers(37.0%). However, no significant difference was observed in females(χ~2=6.019, P=0.304).2The relationship between FL and WBC, RBC, HGB, PLT: Compared withthe non-FL group, WBC, RBC and HGB were significantly increased (P＜0.001) and PLT was significantly reduced (P＜0.001) in FL group.3Risk factors for FL: Logistic multivariant regression analysis indicated therisk factors for FL including body mass index (OR=2.857, P=0.000), age(OR=1.287, P=0.000), diastolic pressure (OR=1.392, P=0.000), systolicpressure (OR=1.240, P=0.008), gender (OR=1.569, P=0.000) and ALT(OR=3.918, P=0.000). And then, we analyzed the blood glucose and serumlipid at population of≥40years, indicated that triglyceride (OR=4.151,P=0.000), fasting serum glucose (OR=1.571, P=0.000) and Low-densitylipoprotein cholesterol (LDL-C, OR=1.246, P=0.017) were the risk factors forFL, while high density lipoprotein cholesterol (HDL-C, P=0.664) and serumtotal cholesterol (P=0.887) were not apparent related to FL.Conclusions: The prevalence of FL was varied in different population. The high prevalence of FL was in the male, aged or official population. The riskfactors for FL were BMI, blood pressure, serum glucose, triglyceride andLDL-C levels.Part2Correlation between FL and the other metabolic disordersObjective: To determine the correlated factors of FL's incidence andclinical consequence in the population of health examination.Methods: A total of1428of health examination data from2006to2010inThird Hospital of Hebei Medical University were recruited. The date ofpersonal document, physical examination, laboratory and ultrasonographyexamination were recorded. According to the follow-up results, they weredivided into non-FL group (non-FL, n=977), new FL group (new-FL, n=156),consistent FL group (FL, n=218), FL recovered group (Recovered, n=77).Results:1General status analysis: During the period of2006to2010, the prevalencerates of FL, obesity, hypertension, diabetes mellitus and hyper-triglyceridemiawere increased significantly. Hypercholesterolemia had not increasedsignificantly (P=0.445).2The incidence of FL: Of the1133healthy participants (300males and833females) who were disease-free at the baseline examination, the ratio of newcases was13.8%, which included74males (24.7%) and82females (9.8%).The males had a higher incidence of FL than the females (P＜0.05). Afterstratification by sex, the incidence of FL increased with age growing in bothmales and females at the endpoint. The peak incidence was found between50-60years. The incidence of FL was significantly higher in the males thanthat in the females before60years old (χ~2=61.030, P=0.000), but there was nosignificantly difference in different genders after60years old (χ~2=1.180,P=0.309). Recovery of FL was77(26.1%) in295participants who sufferedFL at baseline. There was no significant difference of the FL recovery whencompared the males and females. 3The relationship between the related metabolic disorders and FL3.1The changes of BMI among each group3.1.1New-FL group and Non-FL group: At the baseline, BMI in new-FLgroup was significantly higher than that in non-FL group (24.6±2.4kg/m~2vs.22.5±2.5kg/m~2, P=0.000). At the endpoint, BMI was increased significantly innew-FL group (24.6±2.4kg/m~2vs.25.5±2.6kg/m~2, P=0.003), and no markedincrease was found in the non-FL group (22.5±2.5kg/m~2vs.22.7±2.6kg/m~2,P=0.155), and there was significant difference between the new-FL group andnon-FL group (25.5±2.6kg/m~2vs.22.7±2.6kg/m~2, P=0.000).3.1.2FL group and Recovered group: There was no significant differencebetween the two group's BMI at the baseline (26.1±3.0kg/m~2vs.26.0±2.5kg/m~2, P=0.863). However, at the endpoint, BMI was increased significantlyin FL group (26.1±3.0kg/m~2vs.26.9±2.7kg/m~2, P=0.003) and was decreasedsignificantly in the recovered group (26.0±2.5kg/m~2vs.25.0±2.5kg/m~2,P=0.008). And there was significant difference between the FL group andrecovered group (26.9±2.7kg/m~2vs.25.0±2.5kg/m~2, P=0.000).3.2The prevalence of metabolic disorders among each group3.2.1FL and obesity: The prevalence of obesity was increased significantlyin FL group, new-FL group and non-FL group as follow-up (P＜0.05), butthere was no significant increase in recovered group (P=0.400). And theprevalence of obesity was higher in new-FL group than that in non-FL group(P＜0.05). At the endpoint, the prevalence of obesity was increased in FLgroup than that in recovered group (P＜0.05).3.2.2FL and hypertension: The prevalence of hypertension was increasedsignificantly in FL group, new-FL group and non-FL group as follow-up (P＜0.05), but there was no significant increase in recovered group (P=0.145). Andthe prevalence of hypertension was in a higher level in new-FL group than innon-FL group (P＜0.05).3.2.3FL and diabetes mellitus: The prevalence of diabetes mellitus washigher in new-FL group than that in non-FL group (P＜0.05). And there wasno significant increase in each group with the4years follow-up. 3.2.4FL and hypertriglyceridemia: The prevalence of hypertrigly-ceridemia was increased significantly in FL group, new-FL group and non-FLgroup with follow-up (P＜0.05), but there was no significant increase inrecovered group (P=0.400). And the prevalence of hypertriglyceridemia washigher in new-FL group than that in non-FL group (P＜0.05). At the endpoint,the prevalence of hypertriglyceridemia was higher in FL group than that inrecovered group (P＜0.05).Conclusions: The incidence of FL was13.8%by4years follow-up. FLdevelopment was closely correlated with metabolic disorders. The prevalenceof metabolic disorders in of FL and new-FL population were increaseddramatically, and showed an increasing trend in annual. |
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