Preparation And Activity Of Apigenin Derivatives

Apigenin is one of flavoids, and widely distributed in fruit, vegetables, beans andtea, the highest content of apigenin in celery. According to the molecular structure,Apigenin has unique physiological effects and biological characteristics, and it is anatural antioxidant, as a drop of blood pressure and diastolic blood vessels, preventingatherosclerosis, tumor suppression role et.al. At present, apigenin has been applied inpharmaceutical, food and other industries. As poor water-soluble and intestinalabsorption, apigenin has lower bioavailability in oral and in vivod to some extent.The La(â…¢) complex with apigenin has been synthesized through lanthanumnitrate with apigenin,the complex was characterized by elemental analysis, molarconductance, IR,1H NMR, TG-DSC. The scavenging effect on the superoxide radical(O₂^－), hydroxyl radical (OH) on complexe were studied, and the antitumor activityon cervical cancer cells on complexe were also been studied. Result: by studying thescavenging effect of the complexes on superoxide radical and hydroxyl radical, therecan be seen that the complexes have some antioxidant activity, there is a strongantioxidant on the superoxide anion radical and hydroxyl radical, there is very littleeffect on the DPPH free radical. At the same time, the assay of the anti-tumor activityon cervical cancer cells (Hela) showed that: the inhibitory effect increased withincreasing the concentration; in the same concentration, the inhibitory effect hasenhanced along the longer duration of action of the complexes.The rare earth complexes with apigenin have been synthesized through apigeninwith Ytterbium nitrate, rare earth praseodymium nitrate, nitrate, yttrium nitratehydrate.These complexes were characterized. The experimental results: the Prcomplexes with apigenin showed pale brown, yield of86.18%, thermal weight lossrate is of67.8%; the In complexes with apigenin showed pale brown, yield of77.24%,thermal weight loss rate is of56.3%; the Yb complexes with apigenin showed palebrown, yield of92.32%, thermal weight loss rate is of74.5%; the Y complexes withapigenin showed Blackish green, yield of83.61%, thermal weight loss rate is of73.0%.From the infrared spectrum, we can clearly see that the four groups of apigenincomplexes formation.The target molecule will synthesis with apigenin and cinnamicacid (or cinnamylchloride); the target molecule2will synthesis with apigenin and Hydroxy cinnamicacid(or the functional conservation molecules). According to the experimentalconditions, we will be to exploer the feasibility of design experiments. Results:apigenin molecules is benzene hydroxyl compound, its space is great resistance, the molecular polarity is also large, so this test was not successful; in the final catalystDCC/DMAP action, there has obvious response according to the TLC identification,but not structural identification.