Study Of Effects And Action Mechanisms Of Bioactive Components And Risks Of Parkinson's Disease Or Alzhelmer's Disease

In recent years neurodegenerative diseases have aroused more and more social attention, especially Alzheimer's disease and Parkinson's disease. In this paper, we study of effects and action mechanisms of bioactive components and risks of Parkinson's disease or Alzheimer's disease. The key findings are as follow:(1) Many studies have reported an association between tea drinking and Parkinson's disease (PD). Our purpose is to summarize the available information and evaluate the risk of PD associated with tea drinking. We searched all publications in English language on the association of tea drinking and PD risk and was performed the pooled analysis by Review Manager5.0. In total, eight articles from including1418cases and4250controls were included in the meta-analysis. The pooled odds ratio (95%CI) was0.85(0.74-0.98), which suggests the protective effect of tea drinking in PD risks. Moreover, the summary OR (OR:0.83,95%CI=0.69-0.99) for drinkers of<1cup of tea per day versus non-consumers and that (OR:0.96,95%CI=0.73-1.27) for drinkers of>1cups of tea per day versus non-consumers showed that there was not an apparent dose-response relationship. No indication for publication bias was found. This meta-analysis showed that tea drinking can lower the risk of PD, while no apparent dose-response relationship was found. Further effort is needed to fully understand the mechanism underlying the beneficial effect of tea consumption in lowering PD risk.(2) It has been demonstrated that the active ingredient in tea have strong antioxidant effects, and some ingredients have the ability to bind with the enzyme. So we speculate that the mechanism of tea can protect Parkinson's disease is interaction of the effect of active ingredients of anti-oxidative stress and the combined effect of some active ingredients and target protein in Parkinson's disease. In order to verify this view, this study selected seven kinds combinations, used molecular docking, docking with three target proteins of aromatic L-amino acid decarboxylase, catechol-O-A aminotransferase and monoamine oxidase. The results showed that some of the ingredients has a strong binding activity with the target protein in Parkinson's disease, which bears out our hypothesis, and explains the protective mechanism of tea in Parkinson's disease.(3) In view of the vital role of oxidative stress in the pathogenesis of Alzheimer's disease (AD), the potential of antioxidant supplements to prevent AD have gained much interest, while there are conflicting results on this topic in recent years. The purpose of the present study is to comprehensively evaluate the association between dietary intakes, instead of supplements, of the most common three antioxidants (vitamin E, vitamin C, and β-carotene) and the risk of AD on the basis of the meta-analysis studies published up to October2011in Medline and Scopus databases. In total, seven articles were included in the meta-analysis. According to the pooled relative risk (95%CI)0.76(0.67-0.84) for vitamin E, and0.83(0.72-0.94) for vitamin C and0.88(0.73-1.03) for (3-carotene, dietary intakes of the three antioxidants can lower the risk of AD, and vitamin E exhibit the most pronounced protective effects. The findings will be of significance to the prevention and interventional treatment of AD.