Immunohistochemical Study Of Expression And Significance Of Pleiotrophin, MMP2 In Invasive Breast Carcinoma

ObjectiveThe biological characteristics of breast cancer is a high degree of heterogeneity on the performance of the cancer, according to histopathology, immunohistochemistry and genetic characteristics of genes can be divided into different types, genotyping studies revealed ER, PR , Her-2 three-negative breast cancer with rapid disease progression, the prognosis is relatively poor characteristics of triple negative breast cancer clinical and pathological features of the analysis can provide more treatment-related information.By using immunohistochemical staining method, expression of Pleiotrophin(PTN), MMP2 in breast cancer clinical and pathological features was studied, search for new breast cancer prognostic molecular markers, attempts to reveal both the the intrinsic link between the order for the clinical diagnosis and treatment of breast cancer to provide more information. Materials and methodsAffiliated Hospital of Academy of Military Medical Sciences, Department of Pathology between 2000 to 2011, 103 cases of invasive breast cancer cases, access to relevant medical records, of which 51 patients with triple negative breast cancer, 52 cases of non-triple negative breast cancer, and the other from 10 cases of adjacent tissues as control, the use of immunohistochemistry to detect the expression of PTN and MMP2, were statistically analyzed.ResultsTriple negative breast cancer with age, tumor size, axillary lymph node metastasis, recurrence and distant organ metastasis was no significant difference (P> 0.05), and histological grade was statistically significant correlation (P <0.05 .) PTN expression in breast cancer was 83.5% (86/103), MMP2 positive expression rate was 68% (70/103). Triple negative breast cancer compared with non-triple negative breast cancer, PTN, MMP2 expression was no significant difference (P> 0.05). PTN, MMP2 expression and age, tumor grade, axillary lymph node metastasis were correlated. The expression of PTN and the relevance of MMP2 was significantly (P <0.05).Conclutions1.TNBC compared with non-TNBC, histological grade significantly different, suggesting that the pathological diagnosis of TNBC should arouse enough attention. Both PTN, MMP2 expression was not significantly different, suggesting that the occurrence and development TNBC may have unique signaling pathways.2.PTN and MMP2 expression in breast cancer correlated, indicating that the process of invasion and metastasis of breast cancer, the expression of an imbalance between the two can promote breast cancer invasion and metastasis.3. PTN, MMP2 and age of onset of breast cancer, tumor grade, axillary lymph node metastasis, recurrence and distant metastasis have some correlation, suggesting that during the development of breast cancer, PTN, MMP2 may be in a dynamic process, and are subject to refinement and regulation of signaling networks.