Effects Of Life Style Intervention On Glucolipid Metabolism In Normal Glucose Tolerant First-degree Relatives Of Patients With Type 2 Diabetes

Objective To investigate the Characteristic of glucolipid metabolism and the effects of life style intervention on glucolipid metabolism in normal glucose tolerant first-degree relatives of patients with type 2 diabetes.Methods 105 normal glucose tolerant first-degree relatives of patients with type 2 diabetes and 40 healthy subjects were recruited. Body weight(BW),waist circumference (WC),body mass index(BMI),systolic pressure(SBP),diastolic pressure(DBP),fasting blood glucose(FBG), cholesterol(TC),triglycerid(TG),low density lipoprotein(LDL) and HOMA-IR were determined and compared between above two groups.Life style intervention was given to 105 normal glucose tolerant first-degree relatives of patients with type 2 diabetes for one year. BMI, WC, SBP, DBP, FBG, FINS, HOMA-IR, TC, TG, LDL were measured, before and after intervention, and compared.Results The levels of BMI,WC,DBP,TG,TC,LDL, FBG,FINS and HOMA-IR of normal glucose tolerant first-degree relatives of patients with type 2 diabetes were significantly higher than healthy subjects (t=2.094-5.688, Z=4.64,5.26, p<0.05,0.01); The levels of BW,BMI,WC,SBP,DBP, FPG,FINS,HOMA-IR,TG,TC and LDL were significantly lower after intervention than before (t=8.053-13.980, Z=8.225,8.499, P<0.01); The difference of BMI,WC,TG,FINS, HOMA-IR before and after intervention were significantly higher in obesity first-degree relatives of patients with type 2 diabetes than those without obesity (t=3.399～5.256, Z=2.437,2.900, p<0.05,0.01)。 Conclusion There are insulin resistance (IR) and lipid metabolism disorder in normal glucose tolerant first-degree relatives of patients with type 2 diabetes; life style intervention can significantly improve glucose and lipid metabolism in normal glucose tolerant first-degree relatives of patients with type 2 diabetes and can significantly improve levels of TG and IR in obesity normal glucose tolerant first-degree relatives of patients with type 2 diabetes than those without obesity.