Salvia Lyophilized Powder Impact Of Pai-1 Non-st-segment Elevation Myocardial Infarction

Objective:To observe the changes of plasminogen activator inhibitor-1(PAI-1) in non-ST-segment elevatinon myocardial infarction patients and evaluate the efficacy of Danshen freeze-dried powder injection on it.Methods: 110 patients were randomly divided into treatment group and control group. Both groups were given conventional Western medicine treatment, while the treatment group was given extra Danshen freeze-dried powder injection.The plasma PAI-1 levels were detected before treatment and after treatment 14 days. Meanwhile the relationship to occurrence of angina, severe arrhythmia and cardiac dysfunction were evaluated.Results:The plasma PAI-1 levels pre-treatment are close to normal both In the treatment group and the control group. While after 14 days treatment, the plasma PAI-1 level decreased significantly in the treatment group. The incidence rate of angina, severe arrhythmia and cardiac dysfunction in the treatment group were significantly lower than that in the control group.Conclusion:Danshen freeze-dried powder injection for treatment of NSTEMI patients have significantly reduced PAI-1 levels, improved fibrinolytic activity, regulated the balance of fibrinolysis, and reduced the incidence of angina pectoris and serious arrhythmias and improved cardiac function.