| Objective:To investigate the expression of angiotentionⅡtype 2 receptor and the effect of Rosuvastatin on it after vascular balloon injury in rats.Methods:Rat models of aortic endothelial denudation were established by 2F balloon catheters. Rats were randomly allocated into three groups:Group 1 served as controls. Group 2 were given vascular balloon injury. Group 3 were given Rosuvastatin (3mg/kg/d) from 1 day before injury. The expression of AT2 mRNA and protein were investigated at day 14 and 28 after injury by reverse transcription polymerse chain reaction (RT-PCR) technique and immunohistochemistry method, respectively.Results:①Significant intimal thickening was observed at 14 days and 28 days after injury. Rosuvastatin treatment obviously prevented intimal thickening at 14 days and 28 days after injury. (p<0.05, p<0.05).②The expression of AT2 mRNA and protein increased significantly at 14 days and 28 days after injury (p<0.05, p< 0.05),and increased more obviously after Rosuvastatin treatment(p<0.05, p<0.05).Conclusion:①The expression of AT2 increased after balloon injury. Rosuvastatin significantly increased the expression of AT2 and prevented intimal thickening.②The effects of Rosuvastatin on aortic endothelial denudation and regression of vascular remodeling are related with the increased expression of AT2 protein. |
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