| PURPOSE To investigate the metabolism of glucose and lipid in polycystic ovarian syndrome (PCOS) patients, and to investigate the association among hyperandrogenism, obesity, insulin resistance and the metabolism of glucose and lipid in PCOS patients.METHODS 42 patients with PCOS were enrolled in the observation group, which was again divided into two groups by body mass index (BMI) and Homa-IR index(Homa-IRI) respectively. And another 20 normal women were enrolled in the control group. Abdomen circumference, hip circumference, body height, body weight, sex hormone, glucose and lipid were observed respectively. RESULTS①compaired to the controrl group,Low-density lipoprotein(LDL)in the research group was higher(P=0.000), apolipoprotein B (apoB) in the research group was higher (P=0.000), total cholesterol (TC)in the research group was higher(P=0.000), triglyceride(TG) in the research group was higher (P=0.000), apolipoprotein A1 (apoA1) in the research group was lower (P=0.000); Oral glucose tolerance test 2h glucose(OGTT 2h PG) in obese PCOS group was higher (P=0.000), LDL in obese PCOS group was higher (P=0.000), apoB in obese PCOS group was higher (P=0.000), TC in obese PCOS group was higher (P=0.000) TG in obese PCOS group was higher (P=0.000), apoAl in obese PCOS group was lower (P=0.000); LDL in nonobese PCOS group was higher (P=0.000), apoB in nonobese PCOS group was higher (P=0.010), TC in nonobese PCOS group was higher (P=0.001),TG in nonobese PCOS group was higher (P=0.000),apoAl in nonobese PCOS group was lower (P=0.001),fasting glucose(FPG) in nonobese PCOS group was lower (P=0.050); OGTT 2h PG in insulin resistance PCOS group was higher (P=0.010), LDL in insulin resistance PCOS group was higher (P=0.001), apoB in insulin resistance PCOS group was higher (P=0.001), TC in insulin resistance PCOS group was higher (P=0.002), TG in insulin resistance PCOS group was higher (P=0.000), apoAl in insulin resistance PCOS group was lower (P=0.010), high-density lipoprotein (HDL) in insulin resistance PCOS group was lower(P=0.010); LDL in PCOS group without insulin resistance was higher (P=0.000), apoB in PCOS group without insulin resistance was higher (P=0.001), TC in PCOS group without insulin resistance was higher (P=0.001), FPG in PCOS group without insulin resistance was lower (P=0.040), apoAl in PCOS group without insulin resistance was lower (P=0.010).②In the research group, OGTT 2h PG was higher in obese PCOS group than that in the nonobese one (P=0.000), apoB was higher in obese PCOS group than that in the nonobese one (P=0.001), TC was higher in obese PCOS group than that in the nonobese one (P=0.021), TG was higher in obese PCOS group than that in the nonobese one(P=0.021), TG was higher in insulin resistance PCOS group than that in the group without insulin resistance (P=0.000).③Pearson correlation analysis in the PCOS patients:FPG was positively related with dehydroepiandrosterone sulfate (DHEAS) (r=0.321, P=0.038), and negatively related with Homa-β(r=-0.377, P=0.014); OGTT 2h PG was positively related with BMI (r =0.357, P=0.020), abdomen circumference (r=0.373, P=0.015), waist/hip ratio (WHR) (r=0.399, P=0.009), fasting insulin(FINS) (r=0.403, P=0.008), oral glucose tolerance test 2h insulin(OGTT 2h INS) (r=0.576, P=0.000), Homa-IRI (r=0.421, P=0.005), Homa-β(r=0.444, P=0.003), and negatively related with testosterone(T) (r=-0.381, P=0.013); apoB was positively related with BMI (r=0.349, P=0.023), abdomen circumference (r=0.341, P=0.027), and T (r=0.308, P=0.050); HDL was negatively related with DHEAS (r=0.-0.327, P=0.037), and OGTT 2h PG(r=0.-0.335, P=0.031); TC was positively related with abdomen circumference (r=0.389, P=0.011); TG was positively related with BMI (r=0.324, P=0.038), abdomen circumference (r=0.324, P=0.038),WHR (r=0.604, P=0.000), FINS (r=0.604, P=0.000), and Homa-IRI (r=0.383, P=0.013).CONCLUSION The glucose and lipid are abnormal in the PCOS patients. The abnomal metabolism of gucose may be related with obesity and insulin resistance. The abnomal metabolism of lipid may be related with obesity, insulin resistance and hyperandrogenism. |
