The Discussion Of The Relationship Between Plasma B-type Natriuretic Peptide And Ascites , Output Of Urine Potassium And Natrium In Patients With Cirrhosis

Objective: To explore the relationship between plasma B-type natriuretic peptide (BNP) and ascites, discharge quantity of urinary potassium and natrium in patients with cirrhosis.Methods: Plasma BNP levels of 50 patients with cirrhosis and those of conrols (30 patients with the liver disease but without cirrhosis) were compared by t-test. Plasma BNP levels of cirrhotic patients with and without ascites were compared by t-test. Meanwhile plasma BNP levels of cirrhotic patients with and without renal impairment were compared by t-test. The relationship between the plasma B-type natriuretic peptide (BNP) levels of cirrhotic patients and output of 24-hour urine potassium and natrium as well as the ratio urine natrium/urine potassium was evaluated by correlation and multiple regression analysis. The plasma BNP levels of 50 patients with cirrhosis were detected by the analysis of enzyme immune.Results:1. The plasma BNP levels of cirrhosis group were 283.48±711.55 pg/ml, and plasma BNP levels of control group were 48.53±27.7 pg/ml. Plasma BNP levels of cirrhosis group were significantly higher than those of controls(P<0.05).2. Cirrhotic patients with ascites were 32 cases, and plasma BNP levels of them were 274.22±232.13pg/ml, Cirrhotic patients without ascites were 18 cases, and plasma BNP levels of them were 77.13±87.36 pg/ml. Plasma BNP levels of cirrhotic patients with ascites were significantly higher than those of cirrhotic patients without ascites (t=4.293, P<0.001).3. Cirrhotic patients with renal impairment were 17cases, and plasma BNP levels of them were 349.02±276.07pg/ml, Cirrhotic patients without renal impairment were 33 cases, and plasma BNP levels of them were 128.18±122.60 pg/ml. Plasma BNP levels of cirrhotic patients with renal impairment were significantly higher than those of cirrhotic patients without renal impairment ( t=3.142, P<0.05).4. The plasma B-type natriuretic peptide (BNP) levels of cirrhotic patients were significantly related to output of 24-hour urine natrium and the ratio urine natrium/urine potassium (r=0.807, P<0.001 and r=0.817, P<0.001), while plasma BNP levels exhibited no correlation to 24-hour urine potassium(P>0.05). Regression equation was: BNP=-185.71+33.08 urine natrium /urine potassium + 1490.99 urine natrium.Conclusion:1. Plasma BNP levels of cirrhosis group were significantly higher than those of controls. The elevated plasma BNP levels in patients with cirrhosis may reflect the severity of disease.2. Plasma BNP levels of cirrhotic patients with ascites were significantly higher than those of cirrhotic patients without ascites. The plasma B-type natriuretic peptide (BNP) levels were related to cirrhotic patients with ascites.3. Plasma BNP levels of cirrhotic patients with renal impairment were significantly higher than those of cirrhotic patients without renal impairment. The plasma B-type natriuretic peptide (BNP) levels were related to cirrhotic patients with renal impairment.4. The plasma B-type natriuretic peptide (BNP) levels of cirrhotic patients were significantly related to output of 24-hour urine natrium and the ratio urine natrium /urine potassium, while plasma BNP levels exhibited no correlation to 24-hour urine potassium. The result indicated that plasma BNP levels of cirrhotic patients had the effect of discharging urine and urine natrium.