Research Into Type 2 Diabetic Mild Cognitive Impairment Of Enzyme Activity And Amyloid Change And MRI

Objective:This study attemptes to analysis the mild cognitive impairment and imagelolgy of mild Cognitive impairment and Alzheimer disease.The application of MRI imaging techniques explores the relations of insulin degrading enzyme activity, amyloid protein and the degree of cognitive impairment with the MRI characteristics of volume change of hippocampus and mamillary body in cognitive impairment of diabetic and non-diabetic patients, in order to provide the differential diagnosis of diabetes inducing cognitive impairment and Alzheimer's disease in clinic.Methods:We use neuropsychological scales, such as mini-mental state examination (MMSE), the Montreal Cognitive Assessment (MOCA), ADL Scale,Hachinski ischemic index assessment (HIS) and ZUNG's Depression Scale to evaluate memory and cognitive ability.At first, we selected groups of Alzheimer's disease (diabetic group and non-diabetic group) and mild cognitive impairment group (diabetics and non-diabetic group), and made use of the MRI T1 sequences, and then made in perpendicular to the hippocampal in T2 sequence. We manually outlined the axial edge of the MB level and contour to compare the body volume of hippocampus and mamillary. We detectedβ-amyloid protein content, and insulin-degrading enzyme activity in 35 cases of AD and 33 MCI patients By radioimmunoassay (RIA), and analyzed the relationship between (3 amyloid protein content and the variables IDE in patients with AD and MCI.Results:The sensitivity of MoCA is higher than MMSE scale, compared Two groups and two subgroups of MCI and AD:the volume change of the hippocampus and the mamillary body and the IDE activity, Aβbetween MCI group and the T2DM-MCI group is no significant (P> 0.05). compared the two subgroups of AD group and the T2DM-AD group is no significant on MB volume (P> 0.05); IDE activity, Aβlevel, hippocampal volume was significant difference (P<0.05>. All of the MCI patients and AD patients with two groups, hippocampus and MB volume,IDE activity, Aβlevel, which are significant difference owed to statiscal significance. compared all of the MCI patients, hippocampus and MB volume of Alzheimer's disease was narrow, the hippocampus and MB volume of MCI patients with reduced was no significant difference and not significant. comparing AD group, T2DM-AD group IDE activity decreased and amyloid protein content was significantly higher than non-diabetics.Conclusion:1 the early period of MCI and AD manifested memory descending. Examined with MMSE and MoCA conduce to diagnose AD in the early stage. I2 DE andβ-amyloid protein relating to the pathogenesis of AD are new targets for early diagnosis and treatment, which may delay or prevent the incidence of AD,be significant meaningful for diagnos of MCI and AD.Aβclearance and amyloid deposition reducing may be the main treatment goals of AD.3 IDE andβ-amyloid protein can be used as diagnostic indicators of AD patients, and their dynamic test can be used to understand the disease process, which not only helps the diagnosis of AD patients but also has some clinical significance for observation, the dynamic changes and the prognosis.