Treatment Efficiency Of Entecavir And TACE In Patients With Primary Heptatic Carcinoma Of The HBV Copying

ObjectiveTo observe the treatment effect of entecavir Entecavir Capsules(Baraclude) combined with transcatheter arterial chemoembolization in patients with primary hepatic carcinoma of the HBV-DNA copying, to optimize clinical treatment plans of primary liver cancer.MethodsⅠ.We collected the HBV-DNA-positive patients referred to our hospital from March 2005 to March 2010, They are all of primary liver cancer patients that diagnosised by Clinical, image examination, laboratory tests or other means of percutaneous biopsy, excluding other overlapping virus infection,Male 50 cases, female 16 cases,Divided into treatment group (TACE combined with entecavir in treatment) and control group (TACE therapy),we observed the effects of Entecavir combined with TACE for the treatment of primary liver cancer from the improvement of liver function,HBV-DNA level,Child-phug score, quality of life improvement and survival, etc. We collected the patients accord the diagnostic criteria consistent with "primary liver cancer diagnosis and staging" evised by the Guangzhou Committee of the Chinese Liver Cancer Association at September 2001: (1) Diagnosis compliny with Literature[1].(2)Initial treatment or retreatment within 2 months without radiotherapy and chemotherapy. (3) Card's (Kamofasky) score> 50 points. (4) Child classification of liver function above the level B, the kidney function is normal. (5) Expected survival> 3 months.2. Patients were randomly divided into treatment group (40 cases) and control group (26 cases),in gender, age, general condition, liver function, Karnofsky score, Child classification, preoperative routine, the two groups have no significant difference(P>0.05). TACE treatment are given to the two groups, the two groups repeated TACE treatment again after 1-2 months, the treatment group are given entecavir 0.5mg/d, Give immune regulation, liver fuction protection, and other supportive treatment to all patients.3.The operation method of TACE:Using Seldinger technique:Puncture from the femoral artery, Insert the conduit into the hepatic artery,left hepatic artery or right hepatic artery or tumor arteries, inject the chemotherapy drug after determined catheter position by angiography.ResultsThe results showed that:The levels of ALT,TBIL,HBV-DNA,AFP in the treatment group are lower of 2 months,4months (P<0.05, P<0.05, P<0.05), ALB level is higher, Child classification improve than the control group, In improving th e quality of life and prolong survival (P<0.05),the treatment group is better than t he control group (P<0.05)ConclusionTo improve the patients'liver function and prolong survival, the treatment of TACE combined with entecavir have a positive meaning for the patients with prima ry liver cancer of HBV-DNA positive.