Expression And Clinical Significance Of Adhesion Molecule Cd11c In Gastric Carcinoma

Objective To investigate the expression of CD11c in gastric carcinoma and their clinical significance.Methods The expression of CD11c in gastric carcinoma , gastritis tissue and gastric polyp by immunohistochemical assay respectively.Results The expression level of CD11c in gastric carcinoma was higher than that in gastritis tissue and gastric polyp.There are no significant differences of CD11c expression among gender,age, pathological grade, primary area(P>0.05). There are significant differences of CD11c expression among tumor size, lymph node metastasis,invasive depth, histological type, recurrence and clinical stage. The expression of CD11c in tumor size <5cm group(12.4±6.8) was higher than that in tumor size≥5cm group(7.7±4.6), (t=3.98 , P<0.01).The expression of CD11c in non-invasion group(15.4±8.5) was obviously higher than that in invasion group(9.5±5.6), (t=3.1, P<0.05). The expression of CD11c in no lymph node metastasis group(15.3±6.6) was obviously higher than that in lymph node metastasis group (8.6±5.1), (t=5.44, P<0.01). The expression of CD11c in non- recurrence group(12.3±7.4) was higher than that in recurrence group (9.0±5.3), (t=2.90, P<0.01). The expression of CD11c in differentiation group(9.3±5.3) was lower than that in low differentiation group (12.6±7.8), (t=2.68, P<0.01). There were significant diferences among groups of clinical stage(P<0.01). In the multivariate Cox analysis, risk of death with high expression group was significantly lower than that with low expression group(RR=0.51,95%CI=0.22-1.16).Conclusion Detection of CD11c expression in gastric carcinoma will be beneficial to the judgment of the prognosis of gastric carcinoma and the choice of individualized treatment.